ArticleThyroid research2021
Risk factors for transient and permanent congenital hypothyroidism: a population-based case-control study.
Article in Thyroid research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Epidemiological characteristics of congenital hypothyroidism and risk factors for permanent congenital hypothyroidism in Gansu, China.BMC pediatrics · 2026Article
- Association of Certain Maternal and Neonatal Factors with Neonatal Thyroid-Stimulating Hormone Levels: Insights for Congenital Hypothyroidism Prevention.International journal of preventive medicine · 2026Article
- Impact of Maternal and Neonatal Factors on Thyroid-Stimulating Hormone Concentrations in Newborns in Eastern Morocco.Cureus · 2025Article
- Diagnostic options, physiopathology, risk factors and genetic causes of permanent congenital hypothyroidism: A narrative review.Caspian journal of internal medicine · 2024Review
- Two Cases of Congenital Hypothyroidism Revealing Thyroid Agenesis.Medicina (Kaunas, Lithuania) · 2023Article
- Primary Congenital Hypothyroidism in Children Below 3 Years Old - Etiology and Treatment With Overtreatment and Undertreatment Risks, a 5-Year Single Centre Experience.Frontiers in endocrinology · 2022Article
- Diagnostic Re-Evaluation and Potential Predictor Factors of Transient and Permanent Congenital Hypothyroidism in Eutopic Thyroid Gland.Journal of clinical medicine · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongenital hypothyroidism (CH) is the most important cause of mental and physical retardation in newborns. The prevalence of CH has been reported high in East Azerbaijan province of Iran. However, the risk factors for CH are poorly understood. This study aimed to determine and compare risk factors for permanent and transient CH in East Azerbaijan, Iran.
methodsA case-control study was conducted in the Iranian national screening program for CH. This study included 680 neonates: 340 neonates with confirmed CH and 340 matched healthy controls born at the same period and from the same residential area as the cases. Multiple logistic regression analyses were used to estimate the crude and adjusted odds ratios and 95% confidence intervals for the association between different risk factors and transient and permanent CH.
resultsOut of the 680 participants, 364 (53.53%) were male. Family history of CH (OR = 5.09, 95% CI: 1.66-15.63), neonatal jaundice (OR = 3.89, 95% CI: 2.36-6.43) and parental consanguineous relation (OR = 2.19, 95% CI: 1.51-3.17) were associated with an increased risk of permanent CH. Likewise, the use of Betadine in pregnancy (OR = 4.87, 95% CI: 1.45-16.28), family history of CH (OR = 5.98, 95% CI: 2.04-17.48), neonatal jaundice (OR = 2.81, 95% CI: 1.75-4.52), parental consanguineous relation (OR = 3.86, 95% CI: 1.92-5.74), and gestational age at birth (OR = 3.2, 95% CI: 1.90-5.41) were identified as risk factors for transient CH.
conclusionFamily history, neonatal jaundice, gestational age at birth, and Betadine usage in pregnancy are associated with CH.
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