Evidence map›Paper›PMID 33952233›Full record

ArticleBMC public health2021

Risk of stroke and myocardial infarction after influenza-like illness in New York State.

Erin R Kulick, Trevor Alvord, Michelle Canning, Mitchell S V Elkind, Bernard P Chang, Amelia K Boehme

Open access · goldAbstract read
In one paragraph

Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Update on Influenza.The American journal of the medical sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Influence of Influenza Virus Infections in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Erin R KulickDepartment of Epidemiology and Biostatistics, Temple University College of Public Health, 1301 Cecil B Moore Avenue, Ritter Annex 904, Philadelphia, PA, 19122, USA. erin.kulick@temple.edu.ORCID 0000-0001-8650-5357
Trevor AlvordDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Michelle CanningDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Bernard P ChangDepartment of Emergency Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Amelia K BoehmeDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Columbia University · USBrown University · US

Funding

Testing a rapid outpatient management strategy on PTSD, cardiovascular and rehospitalization risk in TIA and minor stroke survivors evaluated in the Emergency DepartmentR01HL141811 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHANG, BERNARD P. · 2018 to 2022
$3.5M
GENERATION OF A MOUSE MODEL FOR SANFILIPPO B SYNDROMEF32NS010141 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, HONG-HUA · 1996 to 1997
–
EEG LEARNING CORRELATES USING SCALP AND INTRACRANIAL ELECTRODESZ01NS001245 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI FEDIO, P · 1985 to 1995
–
NHLBI NIH HHS R01 HL141811NHLBI NIH HHS R01 HL1469NHLBI NIH HHS T32HL13462NIMHD NIH HHS L32 MD001245NINDS NIH HHS F32 NS010141NINDS NIH HHS R03 NS10141NINDS NIH HHS R21 MD01245
6 · The paper itself

Abstract

backgroundInfluenza may be associated with increased stroke and myocardial infarction (MI) risk. We hypothesized that risk of stroke and MI after influenza-like illness (ILI) would be higher in patients in New York State. We additionally assessed whether this relationship differed across a series of sociodemographic factors.

methodsA case-crossover analysis of the 2012-2014 New York Statewide Planning and Research Cooperative System (SPARCS) was used to estimate odds of ischemic stroke and MI after ILI. Each patient's case window (the time period preceding event) was compared to their control windows (same dates from the previous 2 years) in conditional logistic regression models used to estimate odds ratios and 95% confidence intervals (OR, 95% CI). We varied the case windows from 15 to 365 days preceding event as compared to control windows constructed using the same dates from the previous 2 years. Analyses were stratified by sex, race, and urban-rural status based on residential zip code.

resultsA total of 33,742 patients were identified as having ischemic stroke and 53,094 had MI. ILI events in the 15 days prior were associated with a 39% increase in odds of ischemic stroke (95% CI 1.09-1.77), increasing to an almost 70% increase in odds when looking at ILI events over the last year (95% CI 1.56, 1.83). In contrast, the effect of ILI hospitalization on MI was strongest in the 15 days prior (OR = 1.24, 95% CI 1.06-1.44). The risk of ischemic stroke after ILI was higher among individuals living in rural areas in the 90 days prior to stroke and among men in the year prior to event. In contrast, the association between ILI and MI varied only across race with whites having significantly higher ILI associated MI.

conclusionThis study highlights risk period differences for acute cardiovascular events after ILI, indicating possible differences in mechanism behind the risk of stroke after ILI compared to the risk of MI. High risk populations for stroke after ILI include men and people living in rural areas, while whites are at high risk for MI after ILI. Future studies are needed to identify ways to mitigate these risks.

Indexed as

Influenza, HumanMyocardial InfarctionStrokeHumansMaleNew YorkRisk FactorsCardiovascular diseasesCase-crossoverHealth disparitiesInfluenzaMyocardial infarctionStroke

Identifiers

PMID33952233
PMCPMC8097921
OpenAlexW3159890995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.