ArticleBasic and clinical andrology2021
Decline of semen quality over the last 30 years in Uruguay.
Article in Basic and clinical andrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Depression, anxiety, and stress impair sperm quality via dysregulation of the mitochondrial PDK-PDC axis.Reproductive biology and endocrinology : RB&E · 2025Article
- High-Coverage UHPLC-MS/MS Analysis of 67 Mycotoxins in Plasma for Male Infertility Exposure Studies.Toxics · 2024Article
- Frequency, morbidity and equity - the case for increased research on male fertility.Nature reviews. Urology · 2024Review
- Current global status of male reproductive health.Human reproduction open · 2024Review
- Isatin improves oligoasthenospermia caused by busulfan by regulating GSH/GPX4 axis to inhibit ferroptosis.Frontiers in pharmacology · 2024Article
- Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study.BMC public health · 2023Article
- Smoking Induces a Decline in Semen Quality and the Activation of Stress Response Pathways in Sperm.Antioxidants (Basel, Switzerland) · 2023Article
- Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence.Frontiers in endocrinology · 2023Review
- Spatiotemporal trends in human semen quality.Nature reviews. Urology · 2022Review
- Oxidative Stress and Male Infertility: Evidence From a Research Perspective.Frontiers in reproductive health · 2022Review
- Will male semen quality improve with environmental quality?Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the last years, there has been an increasing concern about a global decline in men's fertility. Specifically, some evidence indicates that sperm quality has decreased over the last years. However, reports showing the changes in sperm quality with time are inconsistent. Part of the contradictions between studies is attributed to geographical differences. Surprisingly, few studies include data from South American countries, creating a bias in the conclusions. This study aims to determine how sperm quality has evolved over the past 30 years in Uruguay. For this purpose, 317 medical records from allegedly healthy sperm donor candidates, aged between 18 and 36 years old, who voluntarily requested to be considered as sperm donors between 1988 and 2019, were analyzed. The studied variables were the following sperm parameters: semen volume, sperm cell concentration, total sperm number, progressive motility, vitality, and sperm morphology. A correlative statistical analysis was performed between seminal parameter values and the year data were collected.
resultsWe found a statistically significant decrease in sperm concentration and normal sperm morphology during the studied period. There was no decrease in vitality, seminal volume, and total progressive motility. Semen parameters were not associated with tobacco, drugs, or alcohol consumption.
conclusionsWe conclude that the sperm quality of donor candidates in Uruguay decreased during this period. Further studies should be carried out to verify the occurrence of this phenomenon in the general population and find its possible causes.
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