Evidence map›Paper›PMID 33952156›Full record

ArticleNeuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition2022

Relationship between a novel learning slope metric and Alzheimer's disease biomarkers.

Dustin B Hammers, Kayla Suhrie, Ava Dixon, Brian D Gradwohl, Zane G Archibald, Jace B King, Robert J Spencer, Kevin Duff, John M Hoffman

Abstract read
In one paragraph

Article in Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Evaluating practice effects across learning trials - ceiling effects or something more?Journal of clinical and experimental neuropsychology · 2024
    Article
  3. Article
  4. Article
  5. Learning slopes in early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Validation of and Demographically Adjusted Normative Data for the Learning Ratio Derived from the RAVLT in Robustly Intact Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dustin B HammersCenter for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Kayla SuhrieCenter for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Ava DixonCenter for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Brian D GradwohlMercy Health Hauenstein Neurosciences, Mercy Health, Muskegon, MI, USA.
Zane G ArchibaldCenter for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Jace B KingUtah Center for Advanced Imaging Research, Department of Radiology & Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Robert J SpencerMental Health Service, VA Ann Arbor Healthcare System, Ann Arbor MI, USA.
Kevin DuffCenter for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-9336-2400
John M HoffmanCenter for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Cognitive training and practice effects in MCIR01AG045163 · NIA · UNIVERSITY OF UTAH · PI DUFF, KEVIN M · 2014 to 2018
$2.2M
Siemens MAGNETOM Prisma 3T MRI scannerS10OD018482 · OD · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2015 to 2015
$1.2M
NCATS NIH HHS UL1 TR002538NIA NIH HHS R01 AG045163NIH HHS S10 OD018482
6 · The paper itself

Abstract

The Learning Ratio (LR) is a novel learning score examining the proportion of information learned over successive learning trials relative to information available to be learned. Validation is warranted to understand LR's sensitivity to Alzheimer's disease (AD) pathology. One-hundred twenty-three participants across the AD continuum underwent memory assessment, quantitative brain imaging, and genetic analysis. LR scores were calculated from the HVLT-R, BVMT-R, RBANS List Learning, and RBANS Story Memory, and compared to total hippocampal volumes,

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesApolipoprotein E4BiomarkersBrainHumansAmyloid beta-PeptidesApolipoprotein E4BiomarkersAlzheimer’s diseaseamyloid-PETAPOE ε4Learninglearning slopemild cognitive impairmentMRI

Identifiers

PMID33952156
PMCPMC8568738

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.