Evidence map›Paper›PMID 33951972›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2022

A new aspiration device equipped with a hydro-separator for acute ischemic stroke due to challenging soft and stiff clots.

Naoki Kaneko, Mahsa Ghovvati, Yutaro Komuro, Lea Guo, Kasra Khatibi, Lucido L Ponce Mejia, Hamidreza Saber, Nasim Annabi, Satoshi Tateshima

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In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. In vitro comparison of manual and robotic endovascular thrombectomy for acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Devices and Techniques.Journal of neuroendovascular therapy · 2023
    Review
  10. Engineering a highly elastic bioadhesive for sealing soft and dynamic tissues.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Naoki KanekoDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.ORCID https://orcid.org/0000-0002-3579-7908
Mahsa GhovvatiChemical and Biomolecular Engineering Department, University of California, Los Angeles, USA.
Yutaro KomuroDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Lea GuoDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Kasra KhatibiDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Lucido L Ponce MejiaDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Hamidreza SaberDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Nasim AnnabiChemical and Biomolecular Engineering Department, University of California, Los Angeles, USA.
Satoshi TateshimaDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFragile soft clots and stiff clots remain challenging in the treatment of acute ischemic stroke. This study aims to investigate the impact of clot stiffness on the efficacy of thrombectomy devices and a new aspiration catheter with a hydro-separator.

methodsThe Neurostar aspiration catheter has a novel hydro-separator technology that macerates clots by a stream of saline inside the catheter. The Neurostar catheter and two commercially available devices, the SOFIA aspiration catheter and Solitaire stent retriever, were tested in this study. We evaluated the efficacy of each device on clots with various stiffness in a simple in vitro model. We also assessed single-pass recanalization performance in challenging situations with large erythrocyte-rich clots and fibrin-rich clots in a realistic vascular model.

resultsWe observed an inverse association between the clot stiffness and recanalization rates. The aspiration catheter, SOFIA ingested soft clots but not moderately stiff clots. When removing soft clots with the stent retriever, fragmentation was observed, although relatively stiff clots were well-integrated and removed. The Neurostar ingested soft clots similar to the aspiration catheter, and also aspirated stiff clots by continuous suction with hydro-separator. In the experiments with challenging clots, the Neurostar led to significantly higher recanalization rates than the stent retriever and aspiration catheter.

conclusionsThe stiffness of the clots affected the efficacy of endovascular thrombectomy based on the type of device. The Neurostar catheter with hydro-separator resulted in better success rates than a commercially available aspiration catheter and stent retriever in this experimental model.

Indexed as

Brain IschemiaIschemic StrokeStrokeThrombosisHumansStentsThrombectomyTreatment OutcomeAcute ischemic strokeaspirationclot stiffnessendovascular thrombectomyin vitro model

Identifiers

PMID33951972
PMCPMC8905075
OpenAlexW3158944472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.