ArticleCirculation. Cardiovascular quality and outcomes2021
Progression of Preclinical Heart Failure: A Description of Stage A and B Heart Failure in a Community Population.
Article in Circulation. Cardiovascular quality and outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07185100 (A Prospective, Cross-sectional, Nationwide Community-based Observational Study to Determine the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR), which is not on this map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Cross-sectional, Nationwide Community-based Observational Study to Determine the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Who cites it
22 citing papers in PubMed.
- Effects of dapagliflozin on the progression of left ventricular dysfunction in type 2 diabetes mellitus: a randomized controlled trial.Cardiovascular diabetology · 2025Trial
- Economic evaluation of NT-proBNP testing plus standard clinical assessment versus standard clinical assessment alone for the prevention of heart failure in older adults with type 2 diabetes.BMJ open diabetes research & care · 2026Article
- Development and Validation of a Markov Microsimulation Model for the Economic Evaluation of Methamphetamine-Associated Heart Failure in the United States.Journal of the American Heart Association · 2026Article
- Design and rationale of the WE-CARE-HF-CMR trial: Cardiorenal care on wheels for asymptomatic heart failure patients (NCT07185100).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Preclinical Heart Failure: A Dynamic Trajectory of Progression, Regression, and Risk.Journal of the American Heart Association · 2026Article
- Challenges of Classifying Stage B Heart Failure in a High-Risk Population.Journal of cardiovascular development and disease · 2026Article
- Imaging and Cardiac Biomarker Associations With Preclinical Heart Failure Stage B to C Progression.JACC. Advances · 2026Article
- Evolving role of echocardiography across the heart failure spectrum: from prevention to advanced management.Heart failure reviews · 2025Review
- Prevalence of heart failure stages in elderly population: from a community-dwelling elderly people survey.BMC geriatrics · 2025Article
- Artificial intelligence improves detection and classification of pulmonary venous hypertension related to left ventricular diastolic dysfunction by chest radiography.Scientific reports · 2025Article
- Point-of-care ultrasound can make the difference in patients with heart failure at primary care.Family practice · 2025Article
- Home blood pressure monitoring for improved risk assessment in heart failure: are brachial measurements sufficient?Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes.Journal of translational medicine · 2025Article
- Noninvasive Hemodynamic Assessment by a Sensor Patch: The PATCHWRK (PortAble TeCHnology for Wireless caRdiomyopathy tracKing) Study.JACC. Advances · 2025Article
- The prognostic impact of home blood pressure measurements in patients with stage B heart failure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Association of Impaired Relaxation Mitral Inflow Pattern (Grade 1 Diastolic Function) With Long-Term Noncardiovascular and Cardiovascular Mortality.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2025Article
- HFA-PEFF score as a predictor of worsening heart failure after first-time catheter ablation for atrial fibrillation in patients with preclinical heart failure and preserved ejection fraction.Frontiers in cardiovascular medicine · 2025Article
- Cardiac power output associated with hospitalization and mortality in coronary artery disease patients at stage B heart failure.International journal of cardiology. Heart & vasculature · 2024Article
- Long-term outcomes of phenoclusters in preclinical heart failure with preserved and mildly reduced ejection fraction.ESC heart failure · 2024Article
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe aims of this study are to evaluate the rate of progression of preclinical (Stage A and B) heart failure, identify associated characteristics, and evaluate long-term outcomes.
methodsRetrospective review of the Olmsted County Heart Function Study. Individuals categorized as Stage A or B heart failure at initial visit that returned for a second visit 4 years later were included. Logistic regression analyses evaluated group differences with adjustment for age and sex.
resultsAt visit 1, 413 (32%) individuals were classified as Stage A and 413 (32%) as Stage B. By visit 2, 146 (35%) individuals from Stage A progressed with the vast majority (n=142) progressing to Stage B. In comparison, a total of 23 (6%) individuals progressed from Stage B. A greater rate of progression was seen for Stage A compared with Stage B (8.7 per 100 person-years [95% CI, 7.4-10.2] versus 1.4 per 100 person-years [95% CI, 0.9-2.1];
conclusionsThere is significant progression of preclinical heart failure in a community population, with progression rates higher for Stage A. NT-proBNP correlated with progression for Stage B, but not for Stage A. No statistically significant differences in long-term outcomes were seen. Study results have clinical implications important to help guide future heart failure screening and prevention strategies.
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