Evidence map›Paper›PMID 33951470›Full record

ArticleCell metabolism2021

Mitochondria ensure immune surveillance by retro-communication with the nucleus.

Manuel Rigon, Amelia R Townley, Michelangelo Campanella

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Mitochondria-Nuclear Crosstalk: Orchestrating mtDNA Maintenance.Environmental and molecular mutagenesis · 2025
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Manuel RigonDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Amelia R TownleyDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK.
Michelangelo CampanellaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E6BT London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy. Electronic address: mcampanella@rvc.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria cover several functions within the cell, including an influence on the transcription of nuclear genes. Recent work by Tigano et al. (2021) in Nature has identified a pathway of mitochondrial retrograde communication in which the nucleus senses aberrations in the mtDNA to drive the innate immune response.

Indexed as

Cell NucleusMitochondriaCommunicationDNA, MitochondrialImmunity, InnateDNA, Mitochondrial

Identifiers

PMID33951470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.