Evidence map›Paper›PMID 33951442›Full record

ArticleCell reports2021

Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex.

Eunyoung Kim, Bilal A Bari, Jeremiah Y Cohen

Abstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Learning-dependent gating of hippocampal inputs by frontal interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Article
  4. In Vivo Whole-Cell Recording from the Mouse Brain.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eunyoung KimThe Solomon H. Snyder Department of Neuroscience, Brain Science Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bilal A BariThe Solomon H. Snyder Department of Neuroscience, Brain Science Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeremiah Y CohenThe Solomon H. Snyder Department of Neuroscience, Brain Science Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jeremiah.cohen@jhmi.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Functions of identified dorsal raphe neurons during motivated behaviorR01DA042038 · NIDA · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV · 2016 to 2020
$1.6M
The role of norepinephrine in enabling behavioral change during uncertaintyF30MH110084 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BARI, BILAL ABDUL · 2016 to 2018
$147k
NIDA NIH HHS R01 DA042038NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM136577NIMH NIH HHS F30 MH110084NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS104834
6 · The paper itself

Abstract

Nervous systems maintain information internally using persistent activity changes. The mechanisms by which this activity arises are incompletely understood. We study prefrontal cortex (PFC) in mice performing behaviors in which stimuli predicted rewards at different delays with different probabilities. We measure membrane potential (V

Indexed as

AnimalsMaleMicePrefrontal CortexRewardelectrophysiologymembrane potentialmousepersistent activityprefrontal cortexrewardwhole-cell

Identifiers

PMID33951442
PMCPMC8167820

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.