Evidence map›Paper›PMID 33951431›Full record

ArticleCell reports2021

KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection.

Nicole Caduff, Donal McHugh, Lisa Rieble, Catherine S Forconi, John M Ong'echa, Peter O Oluoch, Ana Raykova, Anita Murer, Michelle Böni, Lara Zuppiger and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. LANA-specific CD4Nature communications · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. The Prevalence of EBV and KSHV in Odontogenic Lesions.International dental journal · 2023
    Article
  18. Review
  19. Review
  20. How Does Epstein-Barr Virus Interact With Other Microbiomes in EBV-Driven Cancers?Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 5 countries.

Nicole CaduffViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Donal McHughViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Lisa RiebleViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Catherine S ForconiDivision of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
John M Ong'echaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Peter O OluochDivision of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Ana RaykovaViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Anita MurerViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Michelle BöniViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Lara ZuppigerViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Thomas F SchulzInstitute of Virology, Hannover Medical School, Hannover and German Centre of Infection Research (DZIF), Hannover-Braunschweig Site, Hannover, Germany.
David J BlackbournSchool of Biosciences and Medicine, University of Surrey, Guildford, UK.
Obinna ChijiokeCellular Immunotherapy, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Ann M MoormannDivision of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. Electronic address: christian.muenz@uzh.ch.
University of Zurich · CHUniversity of Massachusetts Chan Medical School · USKenya Medical Research Institute · KEMedizinische Hochschule Hannover · DEUniversity of Surrey · GB

Funding

Impact of malaria on shaping immunity to EBV in the etiology of Burkitt lymphomaR01CA189806 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MOORMANN, ANN M · 2014 to 2024
$5.7M
NCI NIH HHS R01 CA189806
6 · The paper itself

Abstract

Herpesvirus infections shape the human natural killer (NK) cell compartment. While Epstein-Barr virus (EBV) expands immature NKG2A

Indexed as

AnimalsCell DifferentiationEpstein-Barr Virus InfectionsHerpesvirus 8, HumanHumansKiller Cells, NaturalMiceCD56-negative NK cellsEBVEpstein-Barr virushumanized mouse modelKaposi sarcoma-associated herpesvirusKSHVnatural killer cells

Identifiers

PMID33951431
PMCPMC10285879
OpenAlexW3157584873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.