ArticleAnnals of clinical and translational neurology2021
Interictal spike networks predict surgical outcome in patients with drug-resistant focal epilepsy.
Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Thalamic interictal epileptic and non-epileptic events during NREM sleep in patients with focal epilepsy: a Stereo-EEG study.EBioMedicine · 2026Article
- Mapping intraoperative interictal epileptiform discharges using high-resolution, thin-film cortical arrays.Epilepsia · 2026Article
- Predicting surgical outcome in drug-resistant epilepsy by combining interictal biomarkers within a machine learning framework.Scientific reports · 2026Article
- Predicting Surgical Outcome in Drug-Resistant Epilepsy by Combining Interictal Biomarkers within a Machine Learning Framework.Research square · 2026Article
- Depth-to-scalp spatiotemporal dynamics for stereo-EEG.Epilepsy & behavior reports · 2025Article
- Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state.Brain communications · 2025Article
- Combined MRI morphometry and source imaging guide placement of stereo-EEG electrodes in focal epilepsy with subtle or absent lesions.Frontiers in neurology · 2025Article
- Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.Annals of clinical and translational neurology · 2024Article
- Visualization of the Spatiotemporal Propagation of Interictal Spikes in Temporal Lobe Epilepsy: A MEG Pilot Study.Brain topography · 2024Article
- Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy.Brain communications · 2024Article
- High frequency oscillations in relation to interictal spikes in predicting postsurgical seizure freedom.Scientific reports · 2023Article
- Identifying sources of human interictal discharges with travelling wave and white matter propagation.Brain : a journal of neurology · 2023Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
- Quantitative approaches to guide epilepsy surgery from intracranial EEG.Brain : a journal of neurology · 2023Article
- Interictal MEG abnormalities to guide intracranial electrode implantation and predict surgical outcome.ArXiv · 2023Article
- Interictal magnetoencephalography abnormalities to guide intracranial electrode implantation and predict surgical outcome.Brain communications · 2023Article
- Fast ripples reflect increased excitability that primes epileptiform spikes.Brain communications · 2023Article
- High-rate leading spikes in propagating spike sequences predict seizure outcome in surgical patients with temporal lobe epilepsy.Brain communications · 2023Article
- A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations.Nature communications · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine if properties of epileptic networks could be delineated using interictal spike propagation seen on stereo-electroencephalography (SEEG) and if these properties could predict surgical outcome in patients with drug-resistant epilepsy.
methodsWe studied the SEEG of 45 consecutive drug-resistant epilepsy patients who underwent subsequent epilepsy surgery: 18 patients with good post-surgical outcome (Engel I) and 27 with poor outcome (Engel II-IV). Epileptic networks were derived from interictal spike propagation; these networks described the generation and propagation of interictal epileptic activity. We compared the regions in which spikes were frequent and the regions responsible for generating spikes to the area of resection and post-surgical outcome. We developed a measure termed source spike concordance, which integrates information about both spike rate and region of spike generation.
resultsInclusion in the resection of regions with high spike rate is associated with good post-surgical outcome (sensitivity = 0.82, specificity = 0.73). Inclusion in the resection of the regions responsible for generating interictal epileptic activity independently of rate is also associated with good post-surgical outcome (sensitivity = 0.88, specificity = 0.82). Finally, when integrating the spike rate and the generators, we find that the source spike concordance measure has strong predictability (sensitivity = 0.91, specificity = 0.94). INTERPRETATIONS: Epileptic networks derived from interictal spikes can determine the generators of epileptic activity. Inclusion of the most active generators in the resection is strongly associated with good post-surgical outcome. These epileptic networks may aid clinicians in determining the area of resection during pre-surgical evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.