ArticleAdvanced healthcare materials2021
Drug Release from Thermo-Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants.
Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rational design of immunological programs for functional regenerative niches.Materials today. Bio · 2026Review
- Transducing magnetism to soft responsive shells: smart nanosystems for magneto-triggered release of ibuprofen.RSC advances · 2026Article
- Unveiling the fluorescence lifetime changes of a solvatochromic aurone probe dye upon wetting in an emissive polymer brush matrix by deconvolution of TCSPC data.The European physical journal. E, Soft matter · 2026Article
- Postannealing-Driven Optimization of Humidity Response in Densely and Loosely Grafted Polymer Films.Gels (Basel, Switzerland) · 2026Article
- A sustained living coating for infectious keratitis therapy via probiotic consumption and production effects.Science advances · 2026Article
- Antimicrobial Peptides in Preventive Medicine: Current Perspectives on Coating Strategies.ACS infectious diseases · 2026Review
- Novel Ag-modified zirconia nanomaterials with antibacterial activity.RSC advances · 2026Article
- Fabrication of PAA-RSC advances · 2025Article
- Article
- Functionalization of Cotton by Thermoresponsive Polymer Brushes for Potential Use as Smart Dressings.ACS applied polymer materials · 2025Article
- Direct Measurements of Overlooked Long-Range Interactions near Zwitterionic and Nonionic Polymer Brushes.ACS macro letters · 2025Article
- Salt-Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.Macromolecular bioscience · 2025Article
- A Total Internal Reflection Microscopy (TIRM)-Based Approach for Direct Characterization of Polymer Brush Conformational Change in Aqueous Solution.ACS macro letters · 2024Article
- Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants.ACS applied bio materials · 2024Article
- Controlled swelling of biomaterial devices for improved antifouling polymer coatings.Scientific reports · 2023Article
- Induction Heating Triggers Antibiotic Release and Synergistic Bacterial Killing on Polymer-Coated Titanium Surfaces.Advanced healthcare materials · 2023Article
- Recent Advancements in Metallic Drug-Eluting Implants.Pharmaceutics · 2023Review
- Article
- Advancements in antimicrobial nanoscale materials and self-assembling systems.Chemical Society reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite decades of biomedical advances, the colonization of implant devices with bacterial biofilms is still a leading cause of implant failure. Clearly, new strategies and materials that suppress both initial and later stage bacterial colonization are required in this context. Ideal would be the implementation of a bactericidal functionality in the implants that is temporally and spatially triggered in an autonomous fashion at the infection site. Herein, the fabrication and validation of functional titanium-based implants with triggered antibiotic release function afforded via an intelligent polymer coating is reported. In particular, thermo-responsive poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) brushes on titanium implants synthesized via a surface-initiated atom transfer radical polymerization with activators regenerated through the electron transfer technique (ARGET ATRP) allows for a controlled and thermally triggered release of the antibiotic levofloxacin at the wound site. Antibiotic loaded brushes are investigated as a function of thickness, loading capacity for antibiotics, and temperature. At temperatures of the infection site >37 °C the lower critical solution temperature behavior of the brushes afforded the triggered release. Hence, in addition to the known antifouling effects, the PDEGMA coating ensured enhanced bactericidal effects, as demonstrated in initial in vivo tests with rodents infected with Staphylococcus aureus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.