ArticleJournal of medical virology2021
Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection.
Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Association Between Antioxidants and COVID-19 Outcomes: a Systematic Review on Observational Studies.Biological trace element research · 2023Pooled it
- Pooled it
- Selenium serum levels in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.Journal of nutritional science · 2023Pooled it
- The Associations of Iron Related Biomarkers with Risk, Clinical Severity and Mortality in SARS-CoV-2 Patients: A Meta-Analysis.Nutrients · 2022Pooled it
- The Association Between Prenatal Maternal Selenium Concentration and Neurodevelopment in Early Childhood, Results from a Mother-Child Cohort Study.The Journal of nutrition · 2025Article
- Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.Molecules (Basel, Switzerland) · 2023Review
- Preparation of Zn-Gly and Se-Gly and Their Effects on the Nutritional Quality of Tea (Plants (Basel, Switzerland) · 2023Article
- Review
- Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?-A Comprehensive Review.International journal of molecular sciences · 2022Review
- Article
- Pregnancy and COVID-19: prevention, vaccination, therapy, and beyondTurkish journal of medical sciences · 2021Review
- Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection.Journal of medical virology · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adequate maternal selenium level is essential for immune response and healthy pregnancy. This study aimed to shed light on the selenium status of pregnant women with COVID-19 and the effects of potential deficiency in serum selenium levels. Totally 141 pregnant women, 71 of them were COVID-19 patients, in different trimesters were included in the study. Maternal serum selenium levels, demographic and clinical parameters were determined. Serum selenium levels of pregnant women in the second (p: .0003) and third (p: .001) trimesters with COVID-19 were significantly lower than in the healthy group. Maternal selenium level was found to be negatively correlated with gestational week (p < .0001, r: -.541), D-dimer (p: .0002, r: -.363) and interleukin-6 (IL-6) level (p: .02, r: -.243). In the second trimester, serum selenium level positively correlated with white blood cell (p: .002, r: .424), neutrophil (p: .006, r: .39), lymphocyte (p: .004, r: .410) count and hemoglobin (p: .02, r: .323), hematocrit (p: .008, r: .38) status. In the third trimester, it was found that maternal selenium level positively correlated with monocyte (p: .04, r: .353) and negatively correlated with C-reactive protein level (p: .03, r: -.384). Serum selenium level was gradually decreased during the pregnancy period, however, this natural decrease was enhanced together with COVID-19 infection. The reason might be increased selenium needs depended on the immune response against infection. The decrease in maternal selenium level was found to be related to IL-6 and D-dimer levels, which indicate selenium's role in disease progression.
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