ArticlePloS one2021
Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- Learning induces unique transcriptional landscapes in the auditory cortex.Hearing research · 2023Review
- Learning induces unique transcriptional landscapes in the auditory cortex.bioRxiv : the preprint server for biology · 2023Article
- Activity-dependent regulation of the BAX/BCL-2 pathway protects cortical neurons from apoptotic death during early development.Cellular and molecular life sciences : CMLS · 2023Article
- An unbiased AAV-STARR-seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo.Scientific reports · 2023Article
- Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer's disease mouse brains.Frontiers in cell and developmental biology · 2023Article
- Chromatin compaction precedes apoptosis in developing neurons.Communications biology · 2022Article
- Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition.Frontiers in molecular neuroscience · 2021Article
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Authors and funding
11 authors.
Funding
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Abstract
The interphase nucleus is functionally organized in active and repressed territories defining the transcriptional status of the cell. However, it remains poorly understood how the nuclear architecture of neurons adapts in response to behaviorally relevant stimuli that trigger fast alterations in gene expression patterns. Imaging of fluorescently tagged nucleosomes revealed that pharmacological manipulation of neuronal activity in vitro and auditory cued fear conditioning in vivo induce nucleus-scale restructuring of chromatin within minutes. Furthermore, the acquisition of auditory fear memory is impaired after infusion of a drug into auditory cortex which blocks chromatin reorganization in vitro. We propose that active chromatin movements at the nucleus scale act together with local gene-specific modifications to enable transcriptional adaptations at fast time scales. Introducing a transgenic mouse line for photolabeling of histones, we extend the realm of systems available for imaging of chromatin dynamics to living animals.
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