Evidence map›Paper›PMID 33950695›Full record

ArticleNano letters2021

Ultrasmall Downconverting Nanoparticle for Enhanced Cerenkov Imaging.

Qize Zhang, Edwin C Pratt, Ryo Tamura, Anuja Ogirala, Hsiao-Ting Hsu, Nasim Farahmand, Stephen O'Brien, Jan Grimm

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Article
  6. Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025
    Review
  7. Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qize ZhangMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Edwin C PrattDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Ryo TamuraMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Anuja OgiralaMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Hsiao-Ting HsuMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Nasim FarahmandDepartment of Chemistry and Biochemistry, The City College of New York, 1024 Marshak, 160 Convent Avenue, New York, New York 10031, United States.ORCID 0000-0001-7543-6886
Stephen O'BrienDepartment of Chemistry and Biochemistry, The City College of New York, 1024 Marshak, 160 Convent Avenue, New York, New York 10031, United States.ORCID 0000-0001-7531-8900
Jan GrimmMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0002-5282-9385
Memorial Sloan Kettering Cancer Center · USThe Graduate Center, CUNY · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Smart and self-reporting clinical nano carriers for drug deliveryR01CA215700 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2017 to 2021
$3.5M
Cerenkov luminescence imaging for image-guided cancer surgeryR01CA183953 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2015 to 2019
$2.6M
Cerenkov-emission based nanosensors to detect biologic activities in vivoR01EB014944 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2012 to 2015
$1.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA183953NCI NIH HHS R01 CA215700NIBIB NIH HHS R01 EB014944
6 · The paper itself

Abstract

Cerenkov imaging provides an opportunity to expand the application of approved radiotracers and therapeutic agents by utilizing them for optical approaches, which opens new avenues for nuclear imaging. The dominating Cerenkov radiation is in the UV/blue region, where it is readily absorbed by human tissue, reducing its utility

Indexed as

EuropiumNanoparticlesAnimalsMiceMultimodal ImagingEuropiumCerenkov imagingeuropiumion exchangelanthanide nanomaterialoxidation stateultrasmall

Identifiers

PMID33950695
PMCPMC8879088
OpenAlexW3157244961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.