Evidence map›Paper›PMID 33950681›Full record

ArticleACS chemical neuroscience2021

Drug-Drug Interaction Between Oxycodone and Diazepam by a Combined

Beihong Ji, Ying Xue, Yuanyuan Xu, Shuhan Liu, Albert H Gough, Xiang-Qun Xie, Junmei Wang

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Beihong JiDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15216, United States.ORCID 0000-0003-0387-4056
Ying XueDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, The University of Pittsburgh, 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.
Yuanyuan XuDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, The University of Pittsburgh, 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.
Shuhan LiuDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, The University of Pittsburgh, 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0002-6627-4843
Albert H GoughComputational and Systems Biology, Drug Discovery Institute, The University of Pittsburgh, 800 Murdoch Building, 3420 Forbes Avenue, Pittsburgh, Pennsylvania 15260, United States.
Xiang-Qun XieDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, The University of Pittsburgh, 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.
Junmei WangDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, The University of Pittsburgh, 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0002-9607-8229
National Institute on Drug Abuse · USUniversity of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
NIDA Center of Excellence OF Computational Drug Abuse Research (CDAR)P30DA035778 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, XIE, XIANG-QUN · 2014 to 2018
$5.4M
AMBER force field consortium: a coherent biomolecular simulation platformR01GM079383 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CIEPLAK, PIOTR, DUAN, YONG · 2007 to 2017
$4.7M
Cannabinoid CB2 Receptor Structure and Allosteric ModulatorsR01DA052329 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, XIANG-QUN, ZHANG, CHENG · 2021 to 2024
$2.5M
NCATS NIH HHS UL1 TR001857NIDA NIH HHS P30 DA035778NIDA NIH HHS R01 DA052329NIGMS NIH HHS R01 GM079383
6 · The paper itself

Abstract

Opioids and benzodiazepines have complex drug-drug interactions (DDIs), which serve as an important source of adverse drug effects. In this work, we predicted the DDI between oxycodone (OXY) and diazepam (DZP) in the human body by applying

Indexed as

OxycodonePharmaceutical PreparationsComputer SimulationDiazepamDrug InteractionsHumansModels, BiologicalMolecular Docking SimulationDiazepamOxycodonePharmaceutical Preparationsdiazepamdrug−drug interaction (DDI)MD simulationsmolecular dockingOxycodonepharmacodynamic-DDIpharmacokinetic-DDIphysiologically based pharmacokinetics (PBPK)

Identifiers

PMID33950681
PMCPMC8374491
OpenAlexW3157080558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.