Evidence map›Paper›PMID 33950409›Full record

ReviewClinical & experimental metastasis2022

Mechanisms of breast cancer metastasis.

S David Nathanson, Michael Detmar, Timothy P Padera, Lucy R Yates, Danny R Welch, Thomas C Beadnell, Adam D Scheid, Emma D Wrenn, Kevin Cheung

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical & experimental metastasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

S David NathansonDepartment of Surgery, Henry Ford Cancer Institute, 2799 W Grand Boulevard, Detroit, MI, USA. dnathan1@hfhs.org.ORCID 0000-0002-5254-9789
Michael DetmarInstitute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
Timothy P PaderaDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lucy R YatesWellcome Sanger Institute, Cambridge, UK.
Danny R WelchDepartment of Cancer Biology, University of Kansas Medical Center and University of Kansas Cancer Center, Kansas City, KS, USA.
Thomas C BeadnellDepartment of Cancer Biology, University of Kansas Medical Center and University of Kansas Cancer Center, Kansas City, KS, USA.
Adam D ScheidDepartment of Cancer Biology, University of Kansas Medical Center and University of Kansas Cancer Center, Kansas City, KS, USA.
Emma D WrennTranslational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kevin CheungTranslational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
The University of Kansas Cancer Center · USÉcole Polytechnique Fédérale de Lausanne · CHFred Hutch Cancer Center · USHarvard University · USHenry Ford Health System · USUniversity of Washington · USWellcome Sanger Institute · GB

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Systems biology of lymphatic transportR01HL128168 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L., PADERA, TIMOTHY P · 2015 to 2019
$2.9M
Role of tumor cell cluster-induced signaling in breast cancer metastasisR37CA234488 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Kevin Jon Cheung · 2020 to 2026
$2.8M
Targeting lymph node metastases to prevent cancer progressionR01CA214913 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2017 to 2022
$2.0M
NCI NIH HHS P30 CA168524NCI NIH HHS R01 CA214913NCI NIH HHS R37 CA234488NHLBI NIH HHS R01 HL128168NIGMS NIH HHS P20 GM103418Wellcome TrustWellcome Trust 214584/Z/18/Z
6 · The paper itself

Abstract

Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and other treatments aimed at inhibiting the proliferation of cancer cells. It would be valuable for us to know how breast cancer metastasizes; such knowledge would likely encourage the development of therapies that focus on mechanisms of metastasis and might even allow us to avoid toxic therapies that are currently used for this disease. For example, if we had a drug that targeted a gene that is critical for metastasis, we might even be able to cure a vast majority of patients with breast cancer. By bringing together scientists with expertise in molecular aspects of breast cancer metastasis, and those with expertise in the mechanical aspects of metastasis, this paper probes interesting aspects of the metastasis cascade, further enlightening us in our efforts to improve the outcome from breast cancer treatments.

Indexed as

Breast NeoplasmsMelanomaNeoplasms, Second PrimarySkin NeoplasmsFemaleHumansLymph NodesBreast cancer evolutionCell clustersGenesLymph node and systemic metastasisMitochondrial DNA

Identifiers

PMID33950409
PMCPMC8568733
OpenAlexW3159065019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.