ArticleeLife2021
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation.
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Microtubule-Associated Proteins: From Dynamic Regulation of Microtubules to Cellular Architecture.Cells · 2026Review
- Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites.Science advances · 2026Article
- Structural basis of human γTuRC closure during CM1-activated microtubule nucleation.Nature communications · 2026Article
- The γ-TuRC: mastermind of multipurpose actions at the centrosome.Cellular and molecular life sciences : CMLS · 2026Review
- Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites.bioRxiv : the preprint server for biology · 2025Article
- Structural insights into the interplay between microtubule polymerases, γ-tubulin complexes and their receptors.Nature communications · 2025Article
- Frontiers in integrative structural modeling of macromolecular assemblies.QRB discovery · 2025Review
- Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation.Nature structural & molecular biology · 2024Article
- Structure of the γ-tubulin ring complex-capped microtubule.Nature structural & molecular biology · 2024Article
- γ-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end.The EMBO journal · 2024Article
- Optimizing representations for integrative structural modeling using Bayesian model selection.Bioinformatics (Oxford, England) · 2024Article
- CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC.Nature cell biology · 2024Article
- Optimizing representations for integrative structural modeling using Bayesian model selection.bioRxiv : the preprint server for biology · 2023Article
- Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.The Journal of cell biology · 2023Article
- Microtubule nucleation for spindle assembly: one molecule at a time.Trends in biochemical sciences · 2023Review
- A nucleotide binding-independent role for γ-tubulin in microtubule capping and cell division.The Journal of cell biology · 2023Article
- MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.Molecular biology of the cell · 2023Article
- Article
- How Microtubules Build the Spindle Branch by Branch.Annual review of cell and developmental biology · 2022Review
- The TOG protein Stu2 is regulated by acetylation.PLoS genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Axel F BrilotDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, United States.ORCID 0000-0001-8548-4224
Andrew S LyonDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, United States.ORCID 0000-0001-7681-4981
Alex ZelterDepartment of Biochemistry, University of Washington, Seattle, United States.
Shruthi ViswanathDepartment of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, United States.
Alison MaxwellDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, United States.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, United States.ORCID 0000-0003-1853-0256
Eric G MullerDepartment of Biochemistry, University of Washington, Seattle, United States.
Andrej SaliDepartment of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, United States.ORCID 0000-0003-0435-6197
Trisha N DavisDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID 0000-0003-4797-3152
David A AgardDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, United States.ORCID 0000-0003-3512-695X
University of California, San Francisco · USUniversity of Washington · US
Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MTrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7MTR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8MThe Yeast Centrosome - Structure Assembly & FunctionP01GM105537 · NIGMS · UNIVERSITY OF COLORADO · PI DAVIS, TRISHA N. · 2014 to 2018
$8.3MMicrotubule Nucleation: Structure & MechanismR01GM031627 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A. · 1985 to 2016
$6.1MIMP: Software for Hybrid Determination of Macromolecular Assembly StructuresR01GM083960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2008 to 2024
$5.2MStructure & Mechanism: microtubule nucleation, centrosomes, phage cytoskeletonR35GM118099 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A. · 2016 to 2022
$3.6MMolecular Analysis of Chromosome SegregationR35GM130293 · NIGMS · UNIVERSITY OF WASHINGTON · PI DAVIS, TRISHA N. · 2019 to 2023
$3.5MEliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MCharacterization of a bacteriophage tubulin involved in viral replicationR01GM104556 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AGARD, DAVID A., POGLIANO, JOSEPH A · 2013 to 2016
$1.6MLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kHoward Hughes Medical Institute 0714NIGMS NIH HHS P01 GM105537NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P41 GM103533NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM031627NIGMS NIH HHS R01 GM083960NIGMS NIH HHS R01 GM104556NIGMS NIH HHS R01 GM124149NIGMS NIH HHS R35 GM118099NIGMS NIH HHS R35 GM130293NIH HHS S10 OD020054NIH HHS S10 OD021596NIH HHS S10 OD021741
Abstract
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In
Indexed as
Antigens, NuclearBinding SitesCalmodulin-Binding ProteinsCryoelectron MicroscopyCrystallography, X-RayCytoskeletal ProteinsHumansMass SpectrometryMicrotubule-Organizing CenterMicrotubulesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTubulinAntigens, NuclearCalmodulin-Binding Proteinscentrosomin ACytoskeletal ProteinsSaccharomyces cerevisiae ProteinsSPC110 protein, S cerevisiaeTubulincell biologycytoskeletonelectron microscopymicrotubule nucleationmolecular biophysicsS. cerevisiaestructural biology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.