Evidence map›Paper›PMID 33949873›Full record

ArticleJournal of neurophysiology2021

Functional subgroups of cochlear inner hair cell ribbon synapses differently modulate their EPSC properties in response to stimulation.

Mamiko Niwa, Eric D Young, Elisabeth Glowatzki, Anthony J Ricci

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mamiko NiwaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-1353-3394
Eric D YoungCenter for Hearing and Balance, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0003-0334-408X
Elisabeth GlowatzkiCenter for Hearing and Balance, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3135-658X
Anthony J RicciDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-1706-8904
Johns Hopkins University · USStanford University · US

Funding

The Histology CoreP30DC005211 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI FUCHS, PAUL ALBERT · 2002 to 2016
$9.1M
AFFERENT SYNAPTIC TRANSMISSION IN THE MAMMALIAN COCHLEAR01DC006476 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI GLOWATZKI, ELISABETH · 2004 to 2022
$6.4M
Synaptic Specializations in Auditory Hair CellsR01DC009913 · NIDCD · STANFORD UNIVERSITY · PI RICCI, ANTHONY J · 2009 to 2019
$4.0M
Identification of factors underlying spiral ganglion neurons??? dynamic rangeF32DC013721 · NIDCD · STANFORD UNIVERSITY · PI NIWA, MAMIKO · 2013 to 2016
$168k
HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC006476HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC009913HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) F32DC013721HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) P30DC005211NIDCD NIH HHS F32 DC013721NIDCD NIH HHS P30 DC005211NIDCD NIH HHS R01 DC006476NIDCD NIH HHS R01 DC009913
6 · The paper itself

Abstract

Spiral ganglion neurons (SGNs) form single synapses on inner hair cells (IHCs), transforming sound-induced IHC receptor potentials into trains of action potentials. SGN neurons are classified by spontaneous firing rates as well as their threshold response to sound intensity levels. We investigated the hypothesis that synaptic specializations underlie mouse SGN response properties and vary with pillar versus modiloar synapse location around the hair cell. Depolarizing hair cells with 40 mM K

Indexed as

AnimalsCochleaExcitatory Postsynaptic PotentialsFemaleHair Cells, Auditory, InnerMaleMiceMice, Inbred C57BLNeuronsSpiral GanglionSynapsesauditorydeconvolutioninner hair cellspiral ganglionsynapses

Identifiers

PMID33949873
PMCPMC8285665
OpenAlexW3158758002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.