Evidence map›Paper›PMID 33949807›Full record

ArticleJournal of cachexia, sarcopenia and muscle2021

Association of sarcopenia with mortality and end-stage renal disease in those with chronic kidney disease: a UK Biobank study.

Thomas J Wilkinson, Joanne Miksza, Thomas Yates, Courtney J Lightfoot, Luke A Baker, Emma L Watson, Francesco Zaccardi, Alice C Smith

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 7 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 7 syntheses or guidelines pooled it, 199 citations in OpenAlex.

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  18. Adverse Muscle Composition Is Associated with All-Cause Mortality in CKD: A UK Biobank Imaging Study.Clinical journal of the American Society of Nephrology : CJASN · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thomas J WilkinsonLeicester Kidney Lifestyle Team, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0002-7855-7752
Joanne MikszaLeicester NIHR Biomedical Research Centre, Leicester, UK.
Thomas YatesLeicester NIHR Biomedical Research Centre, Leicester, UK.
Courtney J LightfootLeicester Kidney Lifestyle Team, Department of Health Sciences, University of Leicester, Leicester, UK.
Luke A BakerLeicester Kidney Lifestyle Team, Department of Health Sciences, University of Leicester, Leicester, UK.
Emma L WatsonLeicester Kidney Lifestyle Team, Department of Health Sciences, University of Leicester, Leicester, UK.
Francesco ZaccardiLeicester Real World Evidence Centre, University of Leicester, Leicester, UK.
Alice C SmithLeicester Kidney Lifestyle Team, Department of Health Sciences, University of Leicester, Leicester, UK.
University of Leicester · GBNIHR Leicester Biomedical Research Centre · GB

Funding

British Heart FoundationDepartment of HealthMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Wellcome Trust
6 · The paper itself

Abstract

backgroundSarcopenia, a degenerative and generalized skeletal muscle disorder involving the loss of muscle function and mass, is an under-recognized problem in clinical practice, particularly in chronic kidney disease (CKD). We aimed to investigate the prevalence of sarcopenia in individuals with CKD, its risk factors, and its association with all-cause mortality and progression to end-stage renal disease (ESRD).

methodsUK Biobank participants were grouped according to the presence of CKD (defined as an estimated glomerular filtration rate <60 mL/min/1.73 m

resultsA total of 428 320 participants, of which 8767 individuals with CKD (46% male, aged 62.8 (standard deviation 6.8) years, median estimated glomerular filtration rate 54.5 (interquartile range 49.0-57.7) mL/min/1.72 m

conclusionsParticipants with reduced kidney function are at an increased risk of premature mortality. The presence of sarcopenia increases the risk of mortality and ESRD. Appropriate measurement of sarcopenia should be used to identify at-risk individuals. Interventions such as physical activity should be encouraged to mitigate sarcopenia.

Indexed as

Kidney Failure, ChronicRenal Insufficiency, ChronicSarcopeniaAgedBiological Specimen BanksFemaleHand StrengthHumansMaleUnited KingdomKidney functionMuscle massSarcopeniaStrengthUK Biobank

Identifiers

PMID33949807
PMCPMC8200422
OpenAlexW3158761451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.