ArticleHuman brain mapping2021
Temporal variability of regional intrinsic neural activity in drug-naïve patients with obsessive-compulsive disorder.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluation of Risk of Bias in Neuroimaging-Based Artificial Intelligence Models for Psychiatric Diagnosis: A Systematic Review.JAMA network open · 2023Pooled it
- Abnormalities of Localized Connectivity in Obsessive-Compulsive Disorder: A Voxel-Wise Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- Brain functional abnormalities: a bridge between insulin signaling pathway gene polymorphisms and clinical cognition in early-onset obsessive-compulsive disorder.European child & adolescent psychiatry · 2026Article
- Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study.Translational psychiatry · 2025Article
- Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia.Scientific reports · 2025Article
- Altered static and dynamic amplitude of low-frequency fluctuations in acute carbon monoxide poisoning patients: a resting-state fMRI study.Frontiers in neuroscience · 2025Article
- Static and temporal dynamic changes in brain activity in patients with post-stroke balance dysfunction: a pilot resting state fMRI.Frontiers in neuroscience · 2025Article
- Regional brain activity and connectivity associated with childhood trauma in drug-naive patients with obsessive-compulsive disorder.Scientific reports · 2024Article
- Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.Frontiers in psychiatry · 2024Review
- Resting-State Brain Dynamics Unique to Anxiety in Major Depressive Disorder.Depression and anxiety · 2024Article
- Altered dynamic neural activities in individuals with obsessive-compulsive disorder and comorbid depressive symptoms.Frontiers in psychiatry · 2024Article
- Aberrant spontaneous static and dynamic amplitude of low-frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment.Brain and behavior · 2023Article
- Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning.Neuroscience bulletin · 2023Review
- Sampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry.BMC medicine · 2023Article
- Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder.BMC psychiatry · 2023Article
- Dynamic alterations of spontaneous neural activity in post-stroke aphasia: a resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2023Article
- Abnormal focal segments in left uncinate fasciculus in adults with obsessive-compulsive disorder.Frontiers in psychiatry · 2023Article
- Altered static and dynamic spontaneous neural activity in patients with ischemic pontine stroke.Frontiers in neuroscience · 2023Article
- Disrupted dynamic amplitude of low-frequency fluctuations in patients with active thyroid-associated ophthalmopathy.Frontiers in cell and developmental biology · 2023Article
- Two distinct subtypes of obsessive compulsive disorder revealed by a framework integrating multimodal neuroimaging information.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) displays alterations in regional brain activity represented by the amplitude of low-frequency fluctuation (ALFF), but the time-varying characteristics of this local neural activity remain to be clarified. We aimed to investigate the dynamic changes of intrinsic brain activity in a relatively large sample of drug-naïve OCD patients using univariate and multivariate analyses. We applied a sliding-window approach to calculate the dynamic ALFF (dALFF) and compared the difference between 73 OCD patients and age- and sex-matched healthy controls (HCs). We also utilized multivariate pattern analysis to determine whether dALFF could differentiate OCD patients from HCs at the individual level. Compared with HCs, OCD patients exhibited increased dALFF mainly within regions of the cortical-striatal-thalamic-cortical (CSTC) circuit, including the bilateral dorsal anterior cingulate cortex, medial prefrontal cortex and striatum, and right dorsolateral prefrontal cortex (dlPFC). Decreased dALFF was identified in the bilateral inferior parietal lobule (IPL), posterior cingulate cortex, insula, fusiform gyrus, and cerebellum. Moreover, we found negative correlations between illness duration and dALFF values in the right IPL and between dALFF values in the left cerebellum and Hamilton Depression Scale scores. Furthermore, dALFF can distinguish OCD patients from HCs with the most discriminative regions located in the IPL, dlPFC, middle occipital gyrus, and cuneus. Taken together, in the current study, we demonstrated a characteristic pattern of higher variability of regional brain activity within the CSTC circuits and lower variability in regions outside the CSTC circuits in drug-naïve OCD patients.
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