ArticleThe journal of nutrition, health & aging2021
Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study.
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Prevalence and risk factors of frailty among cardiac surgery patients: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Feasibility of Activity Monitors to Assess Physical Capacity After Critical Illness: An Observational Study Nested Within a Randomized Clinical Trial.Mayo Clinic proceedings. Digital health · 2026Article
- State Racism Index and physical function: The REasons for Geographic and Racial Differences in Stroke (REGARDS) study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Characterization of anemia and its association with functional status and depression in geriatric patients with solid organ cancers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Development and Validation of a Predictive Model for the Risk of Postoperative Frailty in Elderly Patients With Benign Brain Tumors.Brain and behavior · 2026Article
- Prognostic value of the hemoglobin-albumin-lymphocyte-platelet (HALP) score for long-term mortality after transcatheter aortic valve implantation.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026Article
- Anaemia, Iron Deficiency, and Functional Outcomes in Rural Older Indians: Insights from the Odisha Tribal Family Health Survey.The journal of nutrition, health & aging · 2026Article
- Association of serological biomarkers with muscle strength and function in sarcopenia: a cross-sectional study.Annals of medicine · 2025Article
- Article
- Assessing combined effects of risk analysis index-revised (RAI-rev), malnutrition, and anemia on morbidity and mortality after spine surgery for metastatic spinal tumors.Journal of neuro-oncology · 2025Article
- Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- High red blood cell distribution width associated with incident frailty in patients with cardiometabolic diseases: A longitudinal study.Scientific reports · 2025Article
- Composite RAI, Malnutrition, and Anemia Model Superiorly Predicts 30-Day Morbidity and Mortality After Surgery for Adult Spinal Deformity.Journal of clinical medicine · 2025Article
- Construction and validation of a risk prediction model for postoperative frailty in older adults:a multicenter study.BMC geriatrics · 2025Article
- Development and validation of a frailty risk prediction model in patients with peripheral artery disease.Frontiers in surgery · 2025Article
- Verification of haemoglobin level to prevent worsening of prognosis in heart failure with preserved ejection fraction patients from the PURSUIT-HFpEF registry.ESC heart failure · 2024Observational
- Frailty detection with routine blood tests using data from the english longitudinal study of ageing (ELSA).European geriatric medicine · 2024Article
- Frailty and chronic diseases: A bi-directional relationship.Aging medicine (Milton (N.S.W)) · 2024Review
- Iron homeostasis in older adults: balancing nutritional requirements and health risks.The journal of nutrition, health & aging · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe prevalence of anemia and its impact on frailty and physical function amongst the multiethnic older populations in the Southeast Asian (SEA) countries are often not well studied. Singapore, a nation comprised of multiethnic communities, is one of the most rapidly aging population globally. We aim to evaluate the prevalence of anemia and its impact on frailty, and physical function in Healthy Older People Everyday (HOPE)- an epidemiologic population-based study on community-dwelling older adults in Singapore.
designCross-sectional study.
settingCommunity.
participants480 adults ≥ 65 years old. MEASUREMENTS: Data were collected from interviewers-administered questionnaires on socio-demographics, FRAIL scale, Mini-Mental State Examination, EQ-5D, Barthel Index, and Lawton index. Hemoglobin concentration and physical assessments, including anthropometry, grip strength, timed up-and-go (TUG) were measured.
resultsThe overall prevalence of anemia was 15.2% (73 out of 480). The Indian ethnic group had the highest prevalence of anemia (32%, OR=3.02; 95%CI= 1.23-7.41) with the lowest hemoglobin concentration compared to the overall population (13.0±1.3g/L and 13.5±1.4g/L, p=0.02). Hemoglobin levels and anemia were significantly associated with frailty (OR=2.28; 95% CI=1.02-5.10), low grip strength (OR=1.79; 95% CI=1.01-3.03), ≥ one IADL impairment (OR=2.35; 95% CI=1.39-3.97). Each 1 g/dL increase in hemoglobin was associated with a 6% decrease in frailty odds after adjusting for potential covariates (OR = 0.94, 95% CI: 0.90-0.99). There was a significant difference in the mean TUG between the non-anemic (11.0±3.4 seconds) and anemic (12.3±6.0 seconds, p=0.01) counterparts, but no difference in the number of falls.
conclusionIn our multiethnic Asian population, anemia was adversely associated with frailty, decreased muscle strength, and IADL impairment. Health policies on anemia screening should be employed to avoid or potentially delay or reverse these adverse outcomes associated with anemia. Recognition, evaluation, and treatment of anemia amongst this vulnerable population is warranted.
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