ArticleThe journal of nutrition, health & aging2021
Nutritional Status and Risks of Cognitive Decline and Incident Neurocognitive Disorders: Singapore Longitudinal Ageing Studies.
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Change in Cognition Following Ischaemic Stroke.Annals of clinical and translational neurology · 2026Trial
- The effect of milk fat globule membrane phospholipid supplementation on cognitive function in older adults with subjective memory complaints-a randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2025Trial
- Assessing the Adaptive/Maladaptive Strategies of Mastication in Older Taiwanese Individuals Using the Masticatory Adaptation Experience Questionnaire (MAEQ).Journal of oral rehabilitation · 2026Article
- Metformin provides superior neuroprotective potential compared to semaglutide in preventing diabetes-associated Alzheimer's disease via dual actions.Communications medicine · 2026Article
- Association of a novel nutritional index, the triglyceride-cholesterol-body weight index (TCBI), with incident mild cognitive impairment: CHARLS 2011-2018.Frontiers in nutrition · 2026Article
- Associations of Nutritional Health Risk With Cognitive Function in Older Korean Adults: The Mediating Roles of Lower Body Strength and Depression.Geriatrics & gerontology international · 2025Article
- Body mass index-specific metabolic profiles in schizophrenia: implications for cognitive dysfunction and psychopathology.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- The obesity paradox in cognitive decline: Impact of BMI dynamics and APOE genotypes across various cognitive status.Diabetes, obesity & metabolism · 2025Article
- Dual Challenges in the Context of Healthy Aging: A Comprehensive Exploration of the Association between Malnutrition and Cognitive Decline in Disabled Elderly.Aging and disease · 2025Review
- Associations between nutritional status and cognitive impairment in older adults: results from the NHANES 2011-2014 cycles.Frontiers in nutrition · 2025Article
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
- The longitudinal mediating effect of life-space mobility on the relationship between nutritional status and cognitive function in community-dwelling older stroke patients.Frontiers in public health · 2025Article
- Effectiveness of dairy products to protect against cognitive decline in later life: a narrative review.Frontiers in nutrition · 2024Review
- Article
- Dynapenic abdominal obesity is associated with mild cognitive impairment in patients with cardiometabolic disease: a cross-sectional study.BMC geriatrics · 2022Article
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Authors and funding
12 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies suggest that nutritional interventions using the whole diet approach such as the Mediterranean diet may delay cognitive decline and dementia onset. However, substantial numbers of older adults are non-adherent to any ideally healthy dietary pattern and are at risk of malnutrition.
objectiveThe present study investigated the relationship between global malnutrition risk and onsets of cognitive decline and neurocognitive disorders (NCD), including mild cognitive impairment (MCI) or dementia in community-dwelling older adults.
methodsParticipants aged ≥ 55 years in the Singapore Longitudinal Ageing Studies (SLAS) were assessed at baseline using the Elderly Nutritional Indicators for Geriatric Malnutrition Assessment (ENIGMA) and followed up 3-5 years subsequently on cognitive decline (MMSE drop ≥ 2) among 3128 dementia-free individuals, and incident neurocognitive disorders (NCD) among 2640 cognitive normal individuals.
resultsIndividuals at high nutritional risk score (≥ 3) were more likely to develop cognitive decline (OR=1.42, 95%CI=1.01-1.99) and incident MCI-or-dementia (OR=1.64, 95%CI=1.03-2.59), controlling for age, sex, ethnicity, low education, APOE-e4, hearing loss, physical, social, and mental activities, depressive symptoms, smoking, alcohol, central obesity, hypertension, diabetes, low HDL, high triglyceride, cardiac disease, and stroke. Among ENIGMA component indicators, low albumin at baseline was associated with cognitive decline and incident NCD, and 5 or more drugs used, few fruits/vegetables/milk products daily, and low total cholesterol were associated with incident NCD.
conclusionThe ENIGMA measure of global malnutrition risk predicts cognitive decline and incident neurocognitive disorders, suggesting the feasibility of identifying vulnerable subpopulations of older adults for correction of malnutrition risk to prevent neurocognitive disorders.
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