Evidence map›Paper›PMID 33949286›Full record

ArticleJournal of biomolecular structure & dynamics2022

Quantum biochemistry, molecular docking, and dynamics simulation revealed synthetic peptides induced conformational changes affecting the topology of the catalytic site of SARS-CoV-2 main protease.

Jackson L Amaral, Jose T A Oliveira, Francisco E S Lopes, Cleverson D T Freitas, Valder N Freire, Leonardo V Abreu, Pedro F N Souza

Open access · greenAbstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Future microbiology · 2024
    Article
  2. Future virology · 2023
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jackson L AmaralDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.ORCID 0000-0002-8745-1247
Jose T A OliveiraDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.
Francisco E S LopesDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.
Cleverson D T FreitasDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.
Valder N FreireDepartment of Physics, Federal University of Ceará, Fortaleza, Brazil.
Leonardo V AbreuDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.
Pedro F N SouzaDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.ORCID 0000-0003-2524-4434
Universidade Federal do Ceará · BRUniversidade Estadual do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent outbreak caused by SARS-CoV-2 continues to threat and take many lives all over the world. The lack of an efficient pharmacological treatments are serious problems to be faced by scientists and medical staffs worldwide. In this work, an

Indexed as

COVID-19SARS-CoV-2Catalytic DomainCoronavirus 3C ProteasesHumansMolecular Docking SimulationMolecular Dynamics SimulationPeptide HydrolasesPeptidesProtease Inhibitors3C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesPeptide HydrolasesPeptidesProtease InhibitorsCOVID-19SARS-CoV-2 main proteasesynthetic peptides

Identifiers

PMID33949286
PMCPMC8108194
OpenAlexW3157762753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.