Evidence map›Paper›PMID 33949197›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2021

Exfoliated epithelial cell transcriptome reflects both small and large intestinal cell signatures in piglets.

Grace Yoon, Laurie A Davidson, Jennifer S Goldsby, Destiny A Mullens, Ivan Ivanov, Sharon M Donovan, Robert S Chapkin

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Porcine intestinal goblet cells: Guardians of mucosal immunity and barrier function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. From waste to wealth: Repurposing slaughterhouse waste for xenotransplantation.Frontiers in bioengineering and biotechnology · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Grace YoonDepartment of Statistics, Texas A&M University, College Station, Texas.
Laurie A DavidsonDepartment of Nutrition, Texas A&M University, College Station Texas.
Jennifer S GoldsbyDepartment of Nutrition, Texas A&M University, College Station Texas.
Destiny A MullensProgram in Integrative Nutrition & Complex Diseases, Texas A&M University, College Station, Texas.
Ivan IvanovDepartment of Veterinary Pathobiology, Texas A&M University, College Station, Texas.
Sharon M DonovanDepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Illinois.
Robert S ChapkinDepartment of Nutrition, Texas A&M University, College Station Texas.
Texas A&M University · USUniversity of Illinois Urbana-Champaign · US

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Galen Newman · 2019 to 2026
$13.0M
Plasma membrane therapy: Disruption of Wnt associated receptor spatiotemporal organization by membrane targeted dietary bioactives (MTDB)R35CA197707 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN · 2016 to 2022
$6.3M
Dietary and microbial predictors of childhood obesity riskR01DK107561 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHAPKIN, ROBERT STEPHEN, DONOVAN, SHARON MARIE · 2017 to 2021
$2.8M
Nutrition, Biostatistics & Bioinformatics Training GrantT32CA090301 · NCI · TEXAS A&M UNIVERSITY · PI CARROLL, RAYMOND J. · 2016 to 2020
$712k
NCI NIH HHS R35 CA197707NCI NIH HHS T32 CA090301NIDDK NIH HHS R01 DK107561NIEHS NIH HHS P30 ES029067
6 · The paper itself

Abstract

Assessing intestinal development and host-microbe interactions in healthy human infants requires noninvasive approaches. We have shown that the transcriptome of exfoliated epithelial cells in feces can differentiate breast-fed and formula-fed infants and term and preterm infants. However, it is not fully understood which regions of the intestine that the exfoliated cells represent. Herein, the transcriptional profiles of exfoliated cells with that of the ileal and colonic mucosa were compared. We hypothesized that exfoliated cells in the distal colon would reflect mucosal signatures of more proximal regions of the gut. Two-day-old piglets (

Indexed as

AnimalsColonEpithelial CellsGene Expression ProfilingHumansInfant, NewbornInfant, PrematureIntestinal MucosaIntestine, LargeIntestine, SmallSwineTranscriptomecolonileumintestinetranscriptome

Identifiers

PMID33949197
PMCPMC8321797
OpenAlexW3158455519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.