ArticleJournal of biomedical optics2021
Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography.
Article in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Functional dual-slope frequency-domain near-infrared spectroscopy data interpreted with two- and three-layer models.Biophotonics discovery · 2026Article
- Article
- Continuous Wave-Diffuse Optical Tomography (CW-DOT) in Human Brain Mapping: A Review.Sensors (Basel, Switzerland) · 2025Review
- Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers.Journal of biomedical optics · 2025Article
- Phase-based structured interrogation frequency-domain near-infrared spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review.Journal of innovative optical health sciences · 2024Article
- Reflective optical imaging for scattering medium using chaotic laser.Journal of biomedical optics · 2024Article
- Novel data types for frequency-domain diffuse optical spectroscopy and imaging of tissues: characterization of sensitivity and contrast-to-noise ratio for absorption perturbations.Biomedical optics express · 2023Article
- Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.Neurophotonics · 2023Article
- Multi-modulated frequency domain high density diffuse optical tomography.Biomedical optics express · 2022Article
- Lock-in functional near-infrared spectroscopy for measurement of the haemodynamic brain response.Biomedical optics express · 2022Article
- A scalable, multi-wavelength, broad bandwidth frequency-domain near-infrared spectroscopy platform for real-time quantitative tissue optical imaging.Biomedical optics express · 2021Article
- Investigation of effect of modulation frequency on high-density diffuse optical tomography image quality.Neurophotonics · 2021Article
- Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography.Journal of biomedical optics · 2021Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceHigh density diffuse optical tomography (HD-DOT) as applied in functional near-infrared spectroscopy (fNIRS) is largely limited to continuous wave (CW) data. Using a single modulation frequency, frequency domain (FD) HD-DOT has recently demonstrated better localization of focal activation as compared to CW data. We show that combining CW and FD measurements and multiple modulation frequencies increases imaging performance in fNIRS.
aimWe evaluate the benefits of multiple modulation frequencies, combining different frequencies as well as CW data in fNIRS HD-DOT. APPROACH: A layered model was used, with activation occurring within a cortex layer. CW and FD measurements were simulated at 78, 141, and 203 MHz with and without noise. The localization error, full width half maximum, and effective resolution were evaluated.
resultsAcross the average of the three metrics, at 141 MHz, FD performed 8.4% better than CW, and the combination of CW and FD was 21.7% better than CW. FD measurements at 203 MHz performed 5% better than 78 MHz. Moreover, the three combined modulation frequencies of FD and CW performed up to 3.92% better than 141 MHz alone.
conclusionsWe show that combining CW and FD measurements offers better performance than FD alone, with higher modulation frequencies increasing accuracy. Combining CW and FD measurements at multiple modulation frequencies yields the best overall performance.
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