ArticleAngewandte Chemie (International ed. in English)2021
Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Native Chemical Ligation of Peptoid Oligomers.Biochemistry · 2026Article
- The dynamic chemistry of the boron-nitrogen bond.Chemical science · 2026Article
- Chirality Effects in Peptide-Based Dynamic Combinatorial Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Light-Mediated Interconversion between a Foldamer and a Self-Replicator.Journal of the American Chemical Society · 2024Article
- Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent Chemistry.Journal of the American Chemical Society · 2024Article
- Constitutional adaptation to pChemical science · 2024Article
- Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment.Chemical science · 2022Article
- Out-of-Equilibrium Self-Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators.Angewandte Chemie (International ed. in English) · 2022Article
- Carbodiimide-Driven Dimerization and Self-Assembly of Artificial, Ribose-Based Amphiphiles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- An Approach to the De Novo Synthesis of Life.Accounts of chemical research · 2022Article
- Spatiotemporal dynamics of self-assembled structures in enzymatically induced agonistic and antagonistic conditions.Chemical science · 2021Article
- Versatile Polymer Nanocapsules via Redox Competition.Angewandte Chemie (International ed. in English) · 2021Article
- Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators.Angewandte Chemie (International ed. in English) · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nature segregates fundamental tasks such as information storage/transmission and catalysis between two different compound classes (e.g. polynucleotides for replication and folded polyamides for catalysis). This division of labor is likely a product of evolution, raising the question of how simpler systems in which replicators and folded macromolecules co-exist may emerge in the transition from chemistry to biology. In synthetic systems, achieving co-existence of replicators and foldamers in a single molecular network remains an unsolved problem. Previous work on dynamic molecular networks has given rise to either self-replicating fibers or well-defined foldamer structures (or completely un-sorted complex systems). We report a system in which two cross-reactive dithiol (nucleobase- and peptide-based) building blocks self-sort into a replicator fiber and foldamer that both emerge spontaneously and co-exist. The self-sorting behavior remains prevalent across different building block ratios as two phases of emergence occur: replicator growth followed by foldamer formation. This is attributed to the autocatalytic formation of the replicator fiber, followed by enrichment of the system in the remaining building block, which is subsequently incorporated into a foldamer.
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