Evidence map›Paper›PMID 33949040›Full record

ArticleCancer science2021

RAG enhances BCR-ABL1-positive leukemic cell growth through its endonuclease activity in vitro and in vivo.

Meng Yuan, Yang Wang, Mengting Qin, Xiaohui Zhao, Xiaodong Chen, Dandan Li, Yinsha Miao, Wood Otieno Odhiambo, Huasheng Liu, Yunfeng Ma and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Meng YuanDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yang WangDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Mengting QinDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Xiaohui ZhaoDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Xiaodong ChenDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Dandan LiDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yinsha MiaoDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Wood Otieno OdhiamboDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Huasheng LiuDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yunfeng MaDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yanhong JiDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.ORCID https://orcid.org/0000-0003-4144-4786
Xi'an Jiaotong University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNNorthwest University · CN

Funding

National Natural Scientific Foundation of China 81670157National Natural Scientific Foundation of China 81872026
6 · The paper itself

Abstract

BCR-ABL1 gene fusion associated with additional DNA lesions involves the pathogenesis of chronic myelogenous leukemia (CML) from a chronic phase (CP) to a blast crisis of B lymphoid (CML-LBC) lineage and BCR-ABL1

Indexed as

Acid Anhydride HydrolasesAnimalsBlast CrisisCell Line, TumorCell ProliferationCell SurvivalDisease ProgressionDNA-Binding ProteinsDNA Breaks, Double-StrandedDNA End-Joining RepairEndonucleasesFusion Proteins, bcr-ablGenomic InstabilityHeterograftsHistonesHomeodomain ProteinsAcid Anhydride HydrolasesBCR-ABL1 fusion protein, humanDNA-Binding ProteinsEndonucleasesFusion Proteins, bcr-ablH2AX protein, humanHistonesHomeodomain ProteinsMRE11 Homologue ProteinMRE11 protein, humanNuclear ProteinsProtein Kinase InhibitorsRAD50 protein, humanRAG-1 proteinRAG2 protein, humanalternative non-homologous end joining pathwayBCR-ABL1 signalingrecombination-activating genes RAG1 and RAG2tyrosine kinase inhibitorsγ-H2AX

Identifiers

PMID33949040
PMCPMC8253288
OpenAlexW3158859663

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.