Evidence map›Paper›PMID 33949005›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Analysis of differential neonatal lethality in cystathionine β-synthase deficient mouse models using metabolic profiling.

Sapna Gupta, Liqun Wang, Michael J Slifker, Kathy Q Cai, Kenneth N Maclean, Brandi Wasek, Teodoro Bottiglieri, Warren D Kruger

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sapna GuptaCancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Liqun WangCancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Michael J SlifkerBiostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kathy Q CaiCancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kenneth N MacleanDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Brandi WasekCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA.
Teodoro BottiglieriCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA.
Warren D KrugerCancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-4990-3695
Fox Chase Cancer Center · USBaylor Medical Center at Garland · USUniversity of Colorado Denver · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINER01HL057299 · NHLBI · FOX CHASE CANCER CENTER · PI KRUGER, WARREN D · 2001 to 2009
$3.2M
Treatment of CBS Deficiency with Proteostasis ModulatorsR01DK101404 · NIDDK · RESEARCH INST OF FOX CHASE CAN CTR · PI KRUGER, WARREN D · 2014 to 2020
$3.0M
Hyperhomocysteinemia, S-adenosylhomocysteine Accumulation, and EpigeneticsR01GM098772 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI KRUGER, WARREN D · 2012 to 2015
$1.4M
NCI NIH HHS P30 CA006927NHLBI NIH HHS R01 HL057299NIDDK NIH HHS R01 DK101404NIGMS NIH HHS R01 GM098772
6 · The paper itself

Abstract

Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine. Loss of CBS activity due to mutation results in CBS deficiency, an inborn error of metabolism characterized by extreme elevation of plasma total homocysteine (tHcy). C57BL6 mice containing either a homozygous null mutation in the cystathionine β-synthase (Cbs

Indexed as

Disease Models, AnimalMetabolomeMutationAnimalsAnimals, NewbornCystathionine beta-SynthaseFemaleLiver FailureMaleMiceMice, Inbred C57BLMice, TransgenicPhenotypeCystathionine beta-SynthaseHomocysteineinborn errormetabolomicsmethioninemouse models

Identifiers

PMID33949005
PMCPMC8218533
OpenAlexW3157866734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.