Evidence map›Paper›PMID 33948907›Full record

ArticleJournal of racial and ethnic health disparities2022

Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study.

Rumana J Khan, Belinda L Needham, Shailesh Advani, Kristen Brown, Casey Dagnall, Ruihua Xu, Gary H Gibbons, Sharon K Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of racial and ethnic health disparities, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rumana J KhanCardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA. rumana.khan@nih.gov.
Belinda L NeedhamDepartment of Epidemiology, School of Public Health, University of Michigan, 1415, Ann Arbor, Washington Heights, MI, USA.
Shailesh AdvaniCardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA.
Kristen BrownCardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA.
Casey DagnallCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Ruihua XuCardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA.
Gary H GibbonsCardiovascular Disease Section, Metabolic, Cardiovascular and Inflammatory Disease, Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Sharon K DavisCardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA.

Funding

Social Exposures and Genetics of Cardiovascular DiseaseZIAHG200393 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI GIBBONS, GARY · 2014 to 2019
$13.1M
6 · The paper itself

Abstract

purposeWe examined if childhood socioeconomic status (SES) was related to adult leucocyte telomere length (TL) using the data of 361 African American (AA) participants from the GENE-FORECAST Study. We also assessed the mediating role of behavioral and psychosocial factors in the association between childhood SES and adult TL.

methodsChildhood SES was assessed individually by using participant's mother's education and occupation, father's education and occupation, parental home ownership, and family structure. TL was assessed using the quantitative polymerase chain reaction method. Information on potential confounders and mediators were collected. The associations of childhood SES with TL were assessed using multivariable linear regression models. We used path analysis to quantify and test the share of these associations that was statistically explained by each of the mediators (participant's educational attainment, smoking status, physical activity, dietary habit, perceived stress, and depressive symptoms).

resultsMother's education was associated with longer average TL (β: 0.021; 95% CI: 0.001, 0.04, p=0.038) in confounder adjusted models. Once mediators were introduced in the model, the estimates were reduced and remained marginally significant (β: 0.017; 95% CI: -0.003, 0.038, p=0.061). According to path model, approximately 19% of the effect of mother's education on TL (β: 0.004; 95% CI: -0.001, 0.01, p < 0.10) was mediated through participant's own education level. No significant mediation effect was observed for any other mediators.

conclusionsThese data provide evidence that participant's mother's education was positively linked to adult TL in AA population. Participant's own educational level partially explained this association.

Indexed as

Black or African AmericanSocial ClassAdultEducational StatusHumansLeukocytesTelomereAfrican AmericanChildhood socioeconomic statusMediatorMother’s educationPath analysisTelomere length

Identifiers

PMID33948907
PMCPMC9061663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.