ArticleGeroScience2021
Effect of longevity genetic variants on the molecular aging rate.
Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A metabolomic signature of the APOE2 allele.GeroScience · 2023Pooled it
- Dietary patterns and survival to 100 + years: an empty systematic review of cohort and case-control studies.Archives of public health = Archives belges de sante publique · 2022Pooled it
- DREAM repressive activity links somatic mutation, lifespan and disease.Nature aging · 2026Article
- A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genetic architecture of human aging and longevity: Insights from genome-wide association studies.BMB reports · 2026Review
- The DREAM complex links somatic mutation, lifespan, and disease.bioRxiv : the preprint server for biology · 2025Article
- Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity.Scientific reports · 2025Article
- SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.GeroScience · 2025Article
- Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure.The journal of cardiovascular aging · 2025Article
- Race and ethnicity dynamics in survival to 100 years in the United States.Journal of internal medicine · 2025Article
- Exploring the associations of plasma proteins with frailty based on Mendelian randomization.BMC immunology · 2024Article
- yQTL Pipeline: a structured computational workflow for large scale quantitative trait loci discovery and downstream visualization.bioRxiv : the preprint server for biology · 2024Article
- Review
- yQTL Pipeline: A structured computational workflow for large scale quantitative trait loci discovery and downstream visualization.PloS one · 2024Article
- Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.International journal of molecular sciences · 2022Article
- Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data.Frontiers in genetics · 2022Article
- Advances and Utility of the Human Plasma Proteome.Journal of proteome research · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
We conducted a genome-wide association study of 1320 centenarians from the New England Centenarian Study (median age = 104 years) and 2899 unrelated controls using >9 M genetic variants imputed to the HRC panel of ~65,000 haplotypes. The genetic variants with the most significant associations were correlated to 4131 proteins that were profiled in the serum of a subset of 224 study participants using a SOMAscan array. The genetic associations were replicated in a genome-wide association study of 480 centenarians and ~800 controls of Ashkenazi Jewish descent. The proteomic associations were replicated in a proteomic scan of approximately 1000 Ashkenazi Jewish participants from a third cohort. The analysis replicated a protein signature associated with APOE genotypes and confirmed strong overexpression of BIRC2 (p < 5E-16) and under-expression of APOB in carriers of the APOE2 allele (p < 0.05). The analysis also discovered and replicated associations between longevity variants and slower changes of protein biomarkers of aging, including a novel protein signature of rs2184061 (CDKN2A/CDKN2B in chromosome 9) that suggests a genetic regulation of GDF15. The analyses showed that longevity variants correlate with proteome signatures that could be manipulated to discover healthy-aging targets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.