Evidence map›Paper›PMID 33948786›Full record

ArticleEndocrine2021

Association of bone biomarkers with advanced atherosclerotic disease in people with overweight/obesity.

Rossella Del Toro, Ilaria Cavallari, Flavia Tramontana, Kyoungmin Park, Rocky Strollo, Luciana Valente, Mariangela De Pascalis, Francesco Grigioni, Paolo Pozzilli, Raffaella Buzzetti and 2 more

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Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Rossella Del Toro *Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy. r.deltoro@unicampus.it.ORCID 0000-0001-8925-4020
Ilaria Cavallari *Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy.
Flavia TramontanaEndocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Kyoungmin ParkJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Rocky StrolloEndocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Luciana ValenteEndocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Mariangela De PascalisEndocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Francesco GrigioniDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy.
Paolo PozzilliEndocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Raffaella BuzzettiExperimental Medicine Department, Sapienza University of Rome, Rome, Italy.
Nicola NapoliEndocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Ernesto MaddaloniExperimental Medicine Department, Sapienza University of Rome, Rome, Italy.
Università Campus Bio-Medico · ITSapienza University of Rome · ITJoslin Diabetes Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA growing body of evidence suggests a potential link between bone metabolism and cardiovascular disease. Aim of this study was to investigate the relationship between levels of circulating bone turnover biomarkers and advanced atherosclerosis.

methodsKlotho (KL), sclerostin (SOST), osteopontin (OPN) and osteoprotegerin (OPG) were measured in patients undergoing elective coronary angiography and carotid Doppler ultrasound. The primary outcome was the difference in bone biomarkers levels between participants with and without advanced atherosclerosis, defined as the presence of a critical coronary (≥70%) and/or carotid (≥50%) stenosis.

resultsA total of 80 subjects (32.5% females) with a mean age of 68 ± 10 years were included. Advanced atherosclerosis was detected in 55 (68.8%) patients. Subjects with advanced atherosclerosis showed higher serum levels of OPG (p = 0.0015) and SOST (p = 0.017) and similar levels of KL (p = 0.62) and OPN (p = 0.06) compared to patients without. After adjustment for age and sex, only elevated levels of OPG remained significantly associated with advanced atherosclerosis (p = 0.011).

conclusionsHigher serum levels of OPG are independently associated with advanced atherosclerosis confirming a common bond between bone metabolism and vascular disease. Further investigations on the role of selected bone biomarkers in the pathogenesis of cardiovascular disease are needed.

Indexed as

AtherosclerosisOsteoprotegerinAdaptor Proteins, Signal TransducingAgedBiomarkersFemaleGlucuronidaseHumansKlotho ProteinsMaleMiddle AgedObesityOsteopontinOverweightAdaptor Proteins, Signal TransducingBiomarkersGlucuronidaseKlotho ProteinsOsteopontinOsteoprotegerinSOST protein, humanAtherosclerosisBone biomarkersBone-vascular axisCardiovascular disease

Identifiers

PMID33948786
OpenAlexW3159418183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.