Evidence map›Paper›PMID 33948732›Full record

ArticleAmino acids2021

Association between dietary essential amino acids intake and metabolic biomarkers: influence of obesity among Chinese children and adolescents.

Lianlong Yu, Yanmo Li, Qian Zhang, Lichao Zhu, Ning Ding, Bingyin Zhang, Junli Zhang, Wenjie Liu, Suyun Li, Jian Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Lianlong YuNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Yanmo Li *Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Qian Zhang *Law Enforcement and Supervision Bureau of Shandong Provincial Health Commission, Jinan, Shandong, China.
Lichao Zhu *Department of Pediatric Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Ning Ding *Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Bingyin Zhang *Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Junli ZhangShandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Wenjie Liu *Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Suyun Li *Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Jian ZhangNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China. zhangjian@ninh.chinacdc.cn.ORCID http://orcid.org/0000-0001-7931-1044
Shandong Center for Disease Control and Prevention · CNChinese Center For Disease Control and Prevention · CNShandong Provincial Hospital · CNShandong Province Health and Family Planning Commission · CN

Funding

National Key R&D Program [2016YFC1305201] of China 2016YFC1305201Shandong Medical and health Science and Technology Development Project 2019WS436
6 · The paper itself

Abstract

Essential amino acids (EAAs) are involved in growth and development in children and adolescents. This study was aimed at exploring the relationship between dietary EAA intakes and metabolic biomarker, and the influence of obesity in children and adolescents. A total of 3566 subjects were analysed. Participators were classified according to weight status. Metabolic biomarkers were determined using standardized methods and conditions. Normal, overweight, and obesity statuses were defined according to the Working Group on Obesity in China (WGOC) BMI cutoff points based on age- and sex-specific screening criteria. In normal-weight group, blood uric acid was negatively correlated with dietary Ile, Leu, Lys, Phe, Thr, Val, and His, and zinc was negatively correlated with Ile, Leu, Lys, Phe, Thr, Val, His, Met, and Trp. In overweight group, TC was negatively correlated with Ile, Leu, Phe, Val, and His, and LDL-C was negatively correlated with Ile, Leu, Lys, Phe, Thr, Val, His, and Met, while TG was positively correlated with Leu, Lys, Phe, Thr, Val, and Met. In obesity group, hemoglobin was positively related to Ile, Leu, Lys, Phe, Thr, Val, His, and Trp, while vitamin D was positively correlated with His and Trp. The serum creatinine was negatively correlated with Ile, Leu, Phe, Val, His, and Met in normal-weight group, and positively correlated with Ile, Leu, Lys, Phe, Thr, Val, His, Met, Trp, His, and Trp in obesity group. Dietary amino acid score (AAS) and Leu intake were protective factors for obesity. The association between fasting blood glucose and EAAs intake was weak and labile. Metabolic biomarkers and EAA intakes were only related under certain weight status. The dietary AAS is positively correlated with HDL-C, LDL-C, serum creatinine, albumin, serum vitamin D, and zinc. The subtle relationship of EAAs and kidney function should be explored further. There is a complex relationship between EAAs and metabolic biomarkers, and overweight and obesity have a certain influence on this relationship.

Indexed as

AdolescentAmino Acids, EssentialBody WeightChildChinaDietFemaleHumansMaleNutrition SurveysPediatric ObesityAmino Acids, EssentialBiomarkerChildrenDietaryEssential amino acidsMetabolismNutrition

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.