Evidence map›Paper›PMID 33948664›Full record

ArticleSchizophrenia bulletin2021

Need for Ethnic and Population Diversity in Psychosis Research.

Carla Burkhard, Saba Cicek, Ran Barzilay, Rajiv Radhakrishnan, Sinan Guloksuz

Open access · hybridAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Carla BurkhardResearch Master Student in Cognitive and Clinical Neuroscience Psychopathology Program, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Saba CicekDepartment of Psychiatry, Gazi University Medical School, Ankara, Turkey.
Ran BarzilayDepartment of Child and Adolescent Psychiatry and Behavioral Science, Children's Hospital of Philadelphia (CHOP), Philadelphia, PA.
Rajiv RadhakrishnanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT.
Sinan GuloksuzDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT.
Maastricht University · NLGazi University · TRUniversity of Pennsylvania · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mechanisms of resilience to developmental stress in children and adolescents.K23MH120437 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BARZILAY, RAN · 2019 to 2022
$775k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH120437
6 · The paper itself

Abstract

This article aims to evaluate "racial", ethnic, and population diversity-or lack thereof-in psychosis research, with a particular focus on socio-environmental studies. Samples of psychosis research remain heavily biased toward Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. Furthermore, we often fail to acknowledge the lack of diversity, thereby implying that our findings can be generalized to all populations regardless of their social, ethnic, and cultural background. This has major consequences. Clinical trials generate findings that are not generalizable across ethnicity. The genomic-based prediction models are far from being applicable to the "Majority World." Socio-environmental theories of psychosis are solely based on findings of the empirical studies conducted in WEIRD populations. If and how these socio-environmental factors affect individuals in entirely different geographic locations, gene pools, social structures and norms, cultures, and potentially protective counter-factors remain unclear. How socio-environmental factors are assessed and studied is another major shortcoming. By embracing the complexity of environment, the exposome paradigm may facilitate the evaluation of interdependent exposures, which could explain how variations in socio-environmental factors across different social and geographical settings could contribute to divergent paths to psychosis. Testing these divergent paths to psychosis will however require increasing the diversity of study populations that could be achieved by establishing true partnerships between WEIRD societies and the Majority World with the support of funding agencies aspired to foster replicable research across diverse populations. The time has come to make diversity in psychosis research more than a buzzword.

Indexed as

Psychotic DisordersBiomedical ResearchEthnicityHumansPopulation GroupsResearch Subjectsdiversityenvironmentethnicityexposomegeneticshealth disparitiespopulationraceschizophrenia

Identifiers

PMID33948664
PMCPMC8266627
OpenAlexW3157582761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.