Evidence map›Paper›PMID 33948612›Full record

ArticlemedRxiv : the preprint server for health sciences2022

Estimation of local time-varying reproduction numbers in noisy surveillance data.

Wenrui Li, Katia Bulekova, Brian Gregor, Laura F White, Eric D Kolaczyk

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wenrui LiDepartment of Mathematics and Statistics, Boston University, Boston MA, USA.
Katia BulekovaResearch Computing Services, Information Services and Technology, Boston University, Boston MA, USA.
Brian GregorResearch Computing Services, Information Services and Technology, Boston University, Boston MA, USA.
Laura F WhiteDepartment of Biostatistics, Boston University, Boston MA, USA.
Eric D KolaczykDepartment of Mathematics and Statistics, Boston University, Boston MA, USA.

Funding

Maximizing Investigators' Research Award (R35)R35GM141821 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WHITE, LAURA FORSBERG · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM141821
6 · The paper itself

Abstract

A valuable metric in understanding local infectious disease dynamics is the local time-varying reproduction number, i.e. the expected number of secondary local cases caused by each infected individual. Accurate estimation of this quantity requires distinguishing cases arising from local transmission from those imported from elsewhere. Realistically, we can expect identification of cases as local or imported to be imperfect. We study the propagation of such errors in estimation of the local time-varying reproduction number. In addition, we propose a Bayesian framework for estimation of the true local time-varying reproduction number when identification errors exist. And we illustrate the practical performance of our estimator through simulation studies and with outbreaks of COVID-19 in Hong Kong and Victoria, Australia.

Identifiers

PMID33948612
PMCPMC8095231

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.