Evidence map›Paper›PMID 33948573›Full record

ArticleCell reports. Medicine2021

Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities.

Rossana Aprigliano, Merdane Ezgi Aksu, Stefano Bradamante, Boris Mihaljevic, Wei Wang, Kristin Rian, Nicola P Montaldo, Kayla Mae Grooms, Sarah L Fordyce Martin, Diana L Bordin and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Emerging roles for E3 ubiquitin ligases in neural development and disease.Frontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Rossana ApriglianoDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Merdane Ezgi AksuDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Stefano BradamanteDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Boris MihaljevicDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Wei WangDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Kristin RianDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Nicola P MontaldoDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Kayla Mae GroomsDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Sarah L Fordyce MartinDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Diana L BordinDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Matthias BosshardDepartment of Molecular Mechanisms of Disease, University of Zurich, 8057 Zürich, Switzerland.
Yunhui PengComputational Biophysics and Bioinformatics, Department of Physics and Astronomy, Clemson University, Clemson, SC 29631, USA.
Emil AlexovComputational Biophysics and Bioinformatics, Department of Physics and Astronomy, Clemson University, Clemson, SC 29631, USA.
Cindy SkinnerGreenwood Genetic Center, Greenwood, SC 29646, USA.
Nina-Beate LiabakkDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Gareth J SullivanDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0315 Oslo, Norway.
Magnar BjøråsDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Charles E SchwartzGreenwood Genetic Center, Greenwood, SC 29646, USA.
Barbara van LoonDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7049 Trondheim, Norway.
Norwegian University of Science and Technology · NOUniversity of Zurich · CHClemson University · USGreenwood Genetic Center · USOslo University Hospital · NOUniversity of Oslo · NO

Funding

New Generation DelPhi: large systems and beyond electrostaticsR01GM093937 · NIGMS · CLEMSON UNIVERSITY · PI ALEXOV, EMIL GEORGIEV · 2010 to 2023
$4.3M
DelPhi and associated resources: maintenance, development and applicationsR35GM151964 · NIGMS · CLEMSON UNIVERSITY · PI Emil Georgiev Alexov · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM093937NIGMS NIH HHS R35 GM151964
6 · The paper itself

Abstract

Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in

Indexed as

Cell DifferentiationGenes, X-LinkedHumansIntellectual DisabilityMutationTumor Suppressor Protein p53Tumor Suppressor ProteinsUbiquitin-Protein LigasesHUWE1 protein, humanTumor Suppressor Protein p53Tumor Suppressor ProteinsUbiquitin-Protein LigasesE3 ubiquitin ligaseHUWE1neurodevelopmentp53X-linked intellectual disability

Identifiers

PMID33948573
PMCPMC8080178
OpenAlexW3169270828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.