Evidence map›Paper›PMID 33948571›Full record

ReviewCell reports. Medicine2021

Applications of iPSC-derived beta cells from patients with diabetes.

Kristina G Maxwell, Jeffrey R Millman

Open access · goldAbstract readReview
In one paragraph

Review in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
23.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. ProtectiveiScience · 2026
    Article
  5. Review
  6. Review
  7. Type 1 Diabetes Mellitus Pathogenesis: Mechanisms, Early Diagnostic Strategies, and Emerging Therapeutic Approaches.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  8. Experimental models in diabetes research.Laboratory animal research · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. 3D Bioprinting Strategies in Autoimmune Disease Models.International journal of molecular sciences · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Stem cell therapies for diabetes.Nature medicine · 2025
    Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kristina G MaxwellDivision of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeffrey R MillmanDivision of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · US

Funding

Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetesR01DK127497 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MATHEWS, CLAYTON E, MILLMAN, JEFFREY ROBERT · 2020 to 2023
$4.7M
STUDYING THE ROLE OF THE MICROENVIRONMENT ON DIFFERENTIATION AND MATURATION OF BETA CELLSR01DK114233 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Robert Millman · 2017 to 2026
$3.6M
NIDDK NIH HHS R01 DK114233NIDDK NIH HHS R01 DK127497
6 · The paper itself

Abstract

Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These advances are enabling

Indexed as

Cell- and Tissue-Based TherapyCell DifferentiationDiabetes Mellitus, Type 1HumansInduced Pluripotent Stem CellsInsulin-Secreting CellsIslets of Langerhansbeta cellscell therapyCRISPRdiabetesdifferentiationdisease modelingiPS cellsisletspluripotencystem cells

Identifiers

PMID33948571
PMCPMC8080107
OpenAlexW3155244045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.