Evidence map›Paper›PMID 33948570›Full record

ArticleCell reports. Medicine2021

Activated CD4

Sook-San Wong, Christine M Oshansky, Xi-Zhi J Guo, Jacqui Ralston, Timothy Wood, Gary E Reynolds, Ruth Seeds, Lauren Jelley, Ben Waite, Trushar Jeevan and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Identification ofInternational journal of chronic obstructive pulmonary disease · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 5 countries.

Sook-San WongState Key Laboratory for Respiratory Diseases, Guangzhou Medical University, 151 Dongfengxi Road, Yuexiu District, Guangzhou 510000, China.
Christine M OshanskyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xi-Zhi J GuoDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jacqui RalstonInstitute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand.
Timothy WoodInstitute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand.
Gary E ReynoldsImmunisation Advisory Centre, University of Auckland, Auckland, New Zealand.
Ruth SeedsInstitute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand.
Lauren JelleyInstitute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand.
Ben WaiteInstitute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand.
Trushar JeevanDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mark ZaninState Key Laboratory for Respiratory Diseases, Guangzhou Medical University, 151 Dongfengxi Road, Yuexiu District, Guangzhou 510000, China.
Marc-Alain WiddowsonInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Q Sue HuangInstitute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand.
Paul G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Richard J WebbyDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
SHIVERS Investigation Team
St. Jude Children's Research Hospital · USNew Zealand Institute for Public Health and Forensic Science · NZBrigham and Women's Hospital · USCenters for Disease Control and Prevention · USMinistry for Primary Industries · NZUniversity of Auckland · NZ

Funding

NCIRD CDC HHS U01 IP000480NIAID NIH HHS HHSN266200700005C
6 · The paper itself

Abstract

The failure to mount an antibody response following viral infection or seroconversion failure is a largely underappreciated and poorly understood phenomenon. Here, we identified immunologic markers associated with robust antibody responses after influenza virus infection in two independent human cohorts, SHIVERS and FLU09, based in Auckland, New Zealand and Memphis, Tennessee, USA, respectively. In the SHIVERS cohort, seroconversion significantly associates with (1) hospitalization, (2) greater numbers of proliferating, activated CD4

Indexed as

Antibodies, ViralAntibody FormationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansImmunity, MucosalInfluenza A virusInfluenza, HumanInfluenza VaccinesLipopolysaccharide ReceptorsMonocytesOrthomyxoviridae InfectionsAntibodies, ViralCD14 protein, humanInfluenza VaccinesLipopolysaccharide Receptorsantibodycellular immunityhumoral immunityimmune correlateinfectioninfluenzamonocytesmucosal immunityrespiratory virusseroconversion

Identifiers

PMID33948570
PMCPMC8080109
OpenAlexW3147883463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.