Evidence map›Paper›PMID 33948387›Full record

ArticleAmerican journal of cancer research2021

The shifting landscape of genetic alterations separating endometriosis and ovarian endometrioid carcinoma.

Adriana I Gaia-Oltean, Laura A Pop, Roxana M Cojocneanu, Mihail Buse, Andreea A Zimta, Paul Kubelac, Alexandru Irimie, Ovidiu F Coza, Horace Roman, Ioana Berindan-Neagoe

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Establishment of DNA Methylation Profile Associated with TCM Syndrome in Endometriosis.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  10. Article
  11. The Role ofFrontiers in oncology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Adriana I Gaia-OlteanDepartment of Surgical Oncology and Gynecological Oncology, University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca 400012, Romania.
Laura A PopResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj 400337, Romania.
Roxana M CojocneanuResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj 400337, Romania.
Mihail BuseMEDFUTURE Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca 400000, Romania.
Andreea A ZimtaMEDFUTURE Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca 400000, Romania.
Paul KubelacDepartment of Medical Oncology, The Oncology Institute "Ion Chiricuta" Cluj-Napoca, Romania.
Alexandru IrimieDepartment of Surgical Oncology and Gynecological Oncology, University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca 400012, Romania.
Ovidiu F CozaDepartment of Radiotherapy II, The Oncology Institute "Prof. Dr. I Chiricuta" Cluj-Napoca, Cluj 400015, Romania.
Horace RomanCenter of Endometriosis, Clinique Tivoli-Ducos Bordeaux, France.
Ioana Berindan-NeagoeResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj 400337, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · ROEndometriosis · GBInstitute of Oncology Prof. Dr. Ion Chiricuta · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is one of the most common cancers worldwide, and is associated with a prior diagnosis of endometriosis in several cases. Our aim was to correlate genetic and methylation profile of ovarian endometrioid ovarian cancer and endometriosis patients. We evaluated the genetic profile of 50 ovarian endometriosis and 20 ovarian endometrioid carcinoma samples using next generation sequencing technology. In addition, the DNA methylation profile was evaluated for both cohorts of patients. We observed several mutated genes that were common for both types of patients, but we also identified mutated genes that were characteristic for each group:

Indexed as

BRCA1/2Endometriosismethylation profilenext-generation sequencingovarian endometrioid carcinoma

Identifiers

PMID33948387
PMCPMC8085850
OpenAlexW3157424854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.