Evidence map›Paper›PMID 33948331›Full record

ArticleSurgical neurology international2021

The outcome of TSHoma from a tertiary care institute in India.

Aditya Dutta, Nimisha Jain, Ashutosh Rai, Rahul Gupta, Sivashanmugam Dhandapani, Anil Bhansali, Bishan Das Radotra, Chirag Kamal Ahuja, Pinaki Dutta

Abstract read
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In one paragraph

Article in Surgical neurology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aditya DuttaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Nimisha JainDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ashutosh RaiDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Rahul GuptaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sivashanmugam DhandapaniDepartment of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Anil BhansaliDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Bishan Das RadotraDepartment of Histopathology Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Chirag Kamal AhujaDepartment of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Pinaki DuttaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is the rarest functioning pituitary adenoma.

methodsA retrospective analysis of eight patients of TSHomas to highlight the presentations, diagnostic challenges, and treatment outcomes.

resultsMedian age at diagnosis was 42 years, median latency to diagnosis was 2.5 years, and thyrotoxic and compressive symptoms were the most common presenting symptoms. At presentation, three cases were plurihormonal, six cases were on medical treatment including thyroxine, and two cases were incidentally discovered. Imaging revealed macroadenoma in all cases. Seven cases underwent pituitary surgery, after which three achieved remission. Another case entered remission after adjunctive radiotherapy. Thyrotropin (TSH) immunostaining was demonstrated in six out of seven adenomas.

conclusionTSHoma is a rare functioning pituitary tumor with both silent and symptomatic presentations. Diagnosis can be established with biochemical and imaging features, even without dynamic tests.

Indexed as

Non-suppressed thyroid-stimulating hormoneSecondary hyperthyroidismThyroid-stimulating hormone-secreting pituitary adenoma

Identifiers

PMID33948331
PMCPMC8088499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.