ArticleJournal of clinical and translational science2020
A framework for clinical and translational research in the era of rigor and reproducibility.
Article in Journal of clinical and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- From Bench to Bedside: Evolving Definitions of Translational Research.Saudi medical journal · 2026Pooled it
- Proteins targeting ischaemic-reperfusion injury and repair after myocardial infarction: a systematic literature review.Cardiovascular research · 2026Pooled it
- REPCAN: Guideline for REporting Population-based CANcer Registry Data.Asian Pacific journal of cancer prevention : APJCP · 2023Guideline
- A Multiregional Decentralized Clinical Trial Program to Improve Access.JAMA network open · 2026Article
- Ten Healthcare Delivery Trends and Their Measurement and Methodological Implications for Cancer Health Services Research.Health services research · 2026Article
- Evaluating a Mobile Integrated Health Transitional Care Program to Reduce Readmissions: Findings From a Quasi-Experimental Design.Journal of the American Geriatrics Society · 2026Observational
- Implementation research can enhance health research systems and reduce dependency on external aid.PLOS global public health · 2026Article
- Research on the road: Partnering with community emergency medical services to expand access to clinical trials.Journal of clinical and translational science · 2026Article
- Reporting Quality of Meta-Analyses of Randomized Controlled Trials on Knee and Ankle Injury Prevention Programs in Football Players Using PRISMA 2020.Sports (Basel, Switzerland) · 2025Review
- Procedural Physician-Scientists as Catalysts for Innovation in Team Science and Clinical Care.Cancers · 2025Article
- Deep learning MR reconstruction in knees and ankles in children and young adults. Is it ready for clinical use?Skeletal radiology · 2025Article
- Advancing research translation in addiction and pain: A portfolio analysis of the NIH HEAL initiative.Journal of clinical and translational science · 2025Article
- Article
- Waste not, want not: call to action for spinal manipulative therapy researchers.Chiropractic & manual therapies · 2024Article
- Consolidated guidance for behavioral intervention pilot and feasibility studies.Pilot and feasibility studies · 2024Article
- Bridging the gap: a translational perspective in spinal cord injury.Experimental biology and medicine (Maywood, N.J.) · 2024Review
- Expert Perspectives on Pilot and Feasibility Studies: A Delphi Study and Consolidation of Considerations for Behavioral Interventions.Research square · 2023Article
- Banking on a new understanding: translational opportunities from veterinary biobanks.GeroScience · 2023Review
- Program management challenges of clinical studies: A qualitative critical assessment.Journal of family medicine and primary care · 2023Article
- Translational Research in Audiology: Presence in the Literature.Audiology research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
introductionRigor and reproducibility are two important cornerstones of medical and scientific advancement. Clinical and translational research (CTR) contains four phases (T1-T4), involving the translation of basic research to humans, then to clinical settings, practice, and the population, with the ultimate goal of improving public health. Here we provide a framework for rigorous and reproducible CTR.
methodsIn this paper we define CTR, provide general and phase-specific recommendations for improving quality and reproducibility of CTR with emphases on study design, data collection and management, analyses and reporting. We present and discuss aspects of rigor and reproducibility following published examples of CTR from the literature, including one example that shows the development path of different treatments that address anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC).
resultsIt is particularly important to consider robust and unbiased experimental design and methodology for analysis and interpretation for clinical translation studies to ensure reproducibility before taking the next translational step. There are both commonality and differences along the clinical translation research phases in terms of research focuses and considerations regarding study design, implementation, and data analysis approaches.
conclusionsSound scientific practices, starting with rigorous study design, transparency, and team efforts can greatly enhance CTR. Investigators from multidisciplinary teams should work along the spectrum of CTR phases, and identify optimal practices for study design, data collection, data analysis, and results reporting to allow timely advances in the relevant field of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.