Evidence map›Paper›PMID 33948240›Full record

ArticleJournal of clinical and translational science2020

Eight practices for data management to enable team data science.

Andrew McDavid, Anthony M Corbett, Jennifer L Dutra, Andrew G Straw, David J Topham, Gloria S Pryhuber, Mary T Caserta, Steven R Gill, Kristin M Scheible, Jeanne Holden-Wiltse

Registry-linked trialAbstract read
In one paragraph

Article in Journal of clinical and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01789268 (Impact of Respiratory Virus Infections and Bacterial Microbiome Shifts on Lymphocyte and Respiratory Function in Infants Born Prematurely or Full Term), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01789268 completednot on this map

Impact of Respiratory Virus Infections and Bacterial Microbiome Shifts on Lymphocyte and Respiratory Function in Infants Born Prematurely or Full Term

TypeobservationalSponsorUniversity of RochesterRan2013 to 2019Enrolled267ConditionsRespiratory Tract InfectionArmsRespiratory Inductive Plethysmography
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew McDavidDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.ORCID https://orcid.org/0000-0002-6581-1213
Anthony M CorbettClinical and Translational Science Institute, University of Rochester, Rochester, NY, USA.
Jennifer L DutraClinical and Translational Science Institute, University of Rochester, Rochester, NY, USA.
Andrew G StrawDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.
David J TophamDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.
Gloria S PryhuberDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Mary T CasertaDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Steven R GillDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.
Kristin M ScheibleDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Jeanne Holden-WiltseDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn clinical and translational research, data science is often and fortuitously integrated with data collection. This contrasts to the typical position of data scientists in other settings, where they are isolated from data collectors. Because of this, effective use of data science techniques to resolve translational questions requires innovation in the organization and management of these data.

methodsWe propose an operational framework that respects this important difference in how research teams are organized. To maximize the accuracy and speed of the clinical and translational data science enterprise under this framework, we define a set of eight best practices for data management.

resultsIn our own work at the University of Rochester, we have strived to utilize these practices in a customized version of the open source LabKey platform for integrated data management and collaboration. We have applied this platform to cohorts that longitudinally track multidomain data from over 3000 subjects.

conclusionsWe argue that this has made analytical datasets more readily available and lowered the bar to interdisciplinary collaboration, enabling a team-based data science that is unique to the clinical and translational setting.

Indexed as

bioinformaticsData analysisdatabasesdata managementdata sciencepediatricresearch informaticssystems biology

Identifiers

PMID33948240
PMCPMC8057476

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.