Evidence map›Paper›PMID 33948237›Full record

ArticleJournal of clinical and translational science2020

Interrogating an ICD-coded electronic health records database to characterize the epidemiology of prosopagnosia.

Christina Pressl, Caroline S Jiang, Joel Correa da Rosa, Maximilian Friedrich, Roger Vaughan, Winrich A Freiwald, Jonathan N Tobin

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Social Interaction Anxiety in Developmental Prosopagnosia: Prevalence, Severity, and Individual Differences.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Christina PresslLaboratory of Neural Systems, The Rockefeller University, New York, NY, USA.
Caroline S JiangDepartment of Biostatistics, The Rockefeller University, New York, NY, USA.
Joel Correa da RosaDepartment of Explorative Biology, LEO Pharma, Ballerup, Denmark.
Maximilian FriedrichDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Roger VaughanDepartment of Biostatistics, The Rockefeller University, New York, NY, USA.
Winrich A Freiwald *Laboratory of Neural Systems, The Rockefeller University, New York, NY, USA.
Jonathan N Tobin *Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
Rockefeller University · USClinical Directors Network · USUniversitätsklinikum Würzburg · DE

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
NCATS NIH HHS UL1 TR001866
6 · The paper itself

Abstract

introductionRecognition of faces of family members, friends, and colleagues is an important skill essential for everyday life. Individuals affected by prosopagnosia (face blindness) have difficulty recognizing familiar individuals. The prevalence of prosopagnosia has been estimated to be as high as 3%. Prosopagnosia can severely impact the quality of life of those affected, and it has been suggested to co-occur with conditions such as depression and anxiety.

methodsTo determine real-world diagnostic frequency of prosopagnosia and the spectrum of its comorbidities, we utilized a large database of more than 7.5 million de-identified electronic health records (EHRs) from patients who received care at major academic health centers and Federally Qualified Health Centers in New York City. We designed a computable phenotype to search the database for diagnosed cases of prosopagnosia, revealing a total of n = 902 cases. In addition, data from a randomly sampled matched control population (n = 100,973) were drawn from the database for comparative analyses to study the condition's comorbidity landscape. Diagnostic frequency of prosopagnosia, epidemiological characteristics, and comorbidity landscape were assessed.

resultsWe observed prosopagnosia diagnoses at a rate of 0.012% (12 per 100,000 individuals). We discovered elevated frequency of prosopagnosia diagnosis for individuals who carried certain comorbid conditions, such as personality disorder, depression, epilepsy, and anxiety. Moreover, prosopagnosia diagnoses increased with the number of comorbid conditions.

conclusionsResults from this study show a wide range of comorbidities and suggest that prosopagnosia is vastly underdiagnosed. Findings imply important clinical consequences for the diagnosis and management of prosopagnosia as well as its comorbid conditions.

Indexed as

big dataElectronic health records researchepidemiologyprosopagnosiarare diseases

Identifiers

PMID33948237
PMCPMC8057409
OpenAlexW3035780500

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.