Evidence map›Paper›PMID 33948109›Full record

ArticleTherapeutic advances in gastroenterology2021

Potentially inappropriate proton-pump inhibitor prescription in the general population: a claims-based retrospective time trend analysis.

Leander Muheim, Andri Signorell, Stefan Markun, Corinne Chmiel, Stefan Neuner-Jehle, Eva Blozik, Pascale Ursprung, Thomas Rosemann, Oliver Senn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Leander MuheimInstitute of Primary Care, University of Zurich and University Hospital Zurich, Pestalozzistrasse 24, Zurich, 8091, Switzerland.ORCID https://orcid.org/0000-0002-7932-8134
Andri SignorellDepartment of Health Sciences, Helsana Group, Switzerland.
Stefan MarkunInstitute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Corinne ChmielInstitute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Stefan Neuner-JehleInstitute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Eva BlozikDepartment of Health Sciences, Helsana Group, Switzerland.
Pascale UrsprungInstitute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Thomas RosemannInstitute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Oliver SennInstitute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
University of Zurich · CHHelsana Group (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProton-pump inhibitors (PPI) are among the most prescribed drugs worldwide, and a large body of evidence raises concerns about their inappropriate use. Previous estimates of inappropriate use varied due to different definitions and study populations.

aimsWe aimed to measure the population-based incidence and time trends of PPI and potentially inappropriate PPI prescriptions (PIPPI) with a novel method, continuously assessing excessive cumulative doses based on clinical practice guidelines. We also assessed association of patient characteristics with PPI prescriptions and PIPPI.

methodsThis was an observational study based on a large insurance claims database of persons aged >18 years with continuous claims records of ⩾12 months. The observation period was January 2012 to December 2017. We assessed the incidence and time trends of PPI prescriptions and PIPPI based on doses prescribed, defining ⩾11.5 g of pantoprazole dose equivalents during any consecutive 365 days (average daily dose >31 mg) as inappropriate.

resultsAmong 1,726,491 eligible persons, the annual incidence of PPI prescriptions increased from 19.7% (2012) to 23.0% (2017), (

conclusionsThis study provides evidence that one of the most prescribed drug groups is commonly prescribed inappropriately in the general population and that this trend is increasing. Multimorbidity and drugs with bleeding risks were strong determinants of PIPPI. Addressing PPI prescriptions exceeding guideline recommendations could reduce polypharmacy and improve patient safety.

Indexed as

inappropriateoverusepolypharmacyPPIproton-pump inhibitors

Identifiers

PMID33948109
PMCPMC8053831
OpenAlexW3154108648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.