Evidence map›Paper›PMID 33947943›Full record

ReviewJournal of human hypertension2021

Role of hypertension in kidney transplant recipients.

Charalampos Loutradis, Pantelis Sarafidis, Smaragdi Marinaki, Miriam Berry, Richard Borrows, Adnan Sharif, Charles J Ferro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of human hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. A European Renal Association (ERA) synopsis for nephrology practice of the 2023 European Society of Hypertension (ESH) Guidelines for the Management of Arterial Hypertension.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Guideline
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Kidney Transplant: More than Immunological Problems.Journal of clinical medicine · 2025
    Review
  12. Article
  13. Observational
  14. Article
  15. Hypertension in kidney transplant recipients.World journal of transplantation · 2022
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Charalampos LoutradisDepartment of Renal Medicine, University Hospitals Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-6387-4176
Pantelis SarafidisDepartment of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-9174-4018
Smaragdi MarinakiDepartment of Nephrology, Laiko General Hospital, National and Kapodistrian University, Athens, Greece.
Miriam BerryDepartment of Renal Medicine, University Hospitals Birmingham, Birmingham, UK.
Richard BorrowsDepartment of Renal Medicine, University Hospitals Birmingham, Birmingham, UK.
Adnan SharifDepartment of Renal Medicine, University Hospitals Birmingham, Birmingham, UK.
Charles J FerroDepartment of Renal Medicine, University Hospitals Birmingham, Birmingham, UK. charles.ferro@uhb.nhs.uk.ORCID http://orcid.org/0000-0003-0577-7081
NIHR Surgical Reconstruction and Microbiology Research Centre · GBAristotle University of Thessaloniki · GRLaiko General Hospital of Athens · GRUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular events are one of the leading causes of mortality in kidney transplant recipients. Hypertension is the most common comorbidity accompanying chronic kidney disease, with prevalence remaining as high as 90% even after kidney transplantation. It is often poorly controlled. Abnormal blood pressure profiles, such as masked or white-coat hypertension, are also extremely common in these patients. The pathophysiology of blood pressure elevation in kidney transplant recipients is complex and includes transplantation-specific risk factors, which are added to the traditional or chronic kidney disease-related factors. Despite these observations, hypertension management has been an under-researched area in kidney transplantation. Thus, relevant evidence derives either from studies in the general population or from small trials in kidney transplant recipients. Based on the relevant guidelines in the general population, lifestyle modifications should probably be applied as the first step of hypertension management in kidney transplant recipients. The optimal pharmacological management of hypertension in kidney transplant recipients is also not clear. Dihydropyridine calcium channel blockers are commonly used as first line agents because of their lack of adverse effects on the kidney, while other antihypertensive drug classes are under-utilised due to fear of the possible haemodynamic consequences on renal function. This review summarizes the existing data on the pathophysiology, diagnosis, prognostic significance and management of hypertension in kidney transplantation.

Indexed as

HypertensionKidney TransplantationAntihypertensive AgentsCalcium Channel BlockersHumansKidneyTransplant RecipientsAntihypertensive AgentsCalcium Channel Blockers

Identifiers

PMID33947943
OpenAlexW3159324039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.