ArticleThe American journal of pathology1988
Ultrastructural evidence of alveolar epithelial injury in idiopathic bronchiolitis obliterans-organizing pneumonia.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 97 citations in OpenAlex.
- Connective tissue disease-associated lung disease in children.Pediatric radiology · 2024Review
- Organizing pneumonia as an initial presentation in a male lupus: A rare case report.Clinical case reports · 2023Article
- The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Rituximab for steroid-resistant organising pneumonia in a woman with rheumatoid arthritis.BMJ case reports · 2022Article
- Post-Coronavirus Disease 2019 Pulmonary Fibrosis: Wait or Needs Intervention.Tuberculosis and respiratory diseases · 2022Review
- Demystifying idiopathic interstitial pneumonia: time for more etiology-focused nomenclature in interstitial lung disease.Expert review of respiratory medicine · 2022Review
- Toll interacting protein protects bronchial epithelial cells from bleomycin-induced apoptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies.Pulmonary medicine · 2020Review
- Alveolar Dynamics and Beyond - The Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis.Frontiers in physiology · 2020Review
- Potential contribution of alveolar epithelial type I cells to pulmonary fibrosis.Bioscience reports · 2017Review
- Interstitial lung diseases-can pathologists arrive at an etiology-based diagnosis? A critical update.Virchows Archiv : an international journal of pathology · 2013Review
- Bronchiolitis obliterans organising pneumonia: a consequence of breast radiotherapy.BMJ case reports · 2012Article
- Rapidly progressive Bronchiolitis Obliterans Organising Pneumonia presenting with pneumothorax, persistent air leak, acute respiratory distress syndrome and multi-organ dysfunction: a case report.Journal of medical case reports · 2008Article
- Inflammation-associated remodelling and fibrosis in the lung - a process and an end point.International journal of experimental pathology · 2007Review
- Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.The American journal of pathology · 2003Article
- Organising pneumonia.Thorax · 2000Review
- Review
- The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.The American journal of pathology · 1991Article
- Intraluminal fibrosis induced unilaterally by lobar instillation of CdCl2 into the rat lung.The American journal of pathology · 1990Article
- Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns.The American journal of pathology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ultrastructural features of idiopathic bronchiolitis obliterans-organizing pneumonia (BOOP) were studied in 9 patients. As expected, the characteristic air space fibrosis was composed of spindled fibroblasts and myofibroblasts arranged concentrically within an electron-lucent stroma. In 6 patients there was evidence of incorporation of air space fibrosis into the interstitium. A surprising finding in all patients was the presence of extensive epithelial damage involving peribronchiolar alveolar septa. Necrosis and sloughing of alveolar lining cells resulted in denuding of epithelial basal laminae. Complex infoldings and deep invaginations of the denuded basal laminae into alveolar septa were common. These ultrastructural changes involving the interstitium are similar to those occurring in the interstitial pneumonias, and suggest that BOOP also results from acute epithelial injury. The different clinical manifestations and prognosis of these entities may relate to the peribronchiolar localization of the epithelial damage in BOOP compared with more diffuse involvement of distal lung in the interstitial pneumonias.
Indexed as
Identifiers
3394793PMC1880633W1480741572What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.