ArticleScientific reports2021
Relaxation capacity of cartilage is a critical factor in rate- and integrity-dependent fracture.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mechanical Properties of Glycated Cracked Articular Cartilage Under Uniaxial and Cyclic Tensile Loading.Annals of biomedical engineering · 2026Article
- Tissue maturation and development of mechanical properties in hyaluronic acid bioink-based cartilaginous constructs.Frontiers in bioengineering and biotechnology · 2026Article
- Electrostatically Reinforced Double Network Granular Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Piezo1-driven mechanotransduction as a key regulator of cartilage degradation in early osteoarthritis.Biomolecules & biomedicine · 2025Article
- Biomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X-linked hypophosphatemia.JBMR plus · 2023Article
- Relations between Structure/Composition and Mechanics in Osteoarthritic Regenerated Articular Tissue: A Machine Learning Approach.International journal of molecular sciences · 2023Article
- High frame rate deformation analysis of knee cartilage by spiral dualMRI and relaxation mapping.Magnetic resonance in medicine · 2023Article
- Optimization of In Situ Indentation Protocol to Map the Mechanical Properties of Articular Cartilage.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Articular cartilage heals poorly but experiences mechanically induced damage across a broad range of loading rates and matrix integrity. Because loading rates and matrix integrity affect cartilage mechanical responses due to poroviscoelastic relaxation mechanisms, their effects on cartilage failure are important for assessing and preventing failure. This paper investigated rate- and integrity-dependent crack nucleation in cartilage from pre- to post-relaxation timescales. Rate-dependent crack nucleation and relaxation responses were obtained as a function of matrix integrity through microindentation. Total work for crack nucleation increased with decreased matrix integrity, and with decreased loading rates. Critical energy release rate of intact cartilage was estimated as 2.39 ± 1.39 to 2.48 ± 1.26 kJ m
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