Evidence map›Paper›PMID 33947892›Full record

ArticleScientific reports2021

Gastrokine-1, an anti-amyloidogenic protein secreted by the stomach, regulates diet-induced obesity.

Anne-Marie C Overstreet, Bernadette E Grayson, Antonia Boger, Danika Bakke, Erin M Carmody, Cayla E Bales, Shirley C Paski, Stephen F Murphy, Christopher R Dethlefs, Kara J Shannon and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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  8. The Interplay betweenInternational journal of molecular sciences · 2023
    Review
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  11. BioMed research international · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Anne-Marie C Overstreet *Department of Microbiology and Immunology, Indiana University School of Medicine-South Bend, RCH122, 1234 N. Notre Dame Ave., South Bend, IN, 46617, USA.
Bernadette E Grayson *Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Antonia BogerDepartment of Microbiology and Immunology, Indiana University School of Medicine-South Bend, RCH122, 1234 N. Notre Dame Ave., South Bend, IN, 46617, USA.
Danika BakkeDepartment of Microbiology and Immunology, Indiana University School of Medicine-South Bend, RCH122, 1234 N. Notre Dame Ave., South Bend, IN, 46617, USA.
Erin M CarmodyDepartment of Biology, University of Notre Dame, South Bend, IN, USA.
Cayla E BalesDepartment of Biology, University of Notre Dame, South Bend, IN, USA.
Shirley C PaskiCedars-Sinai Medical Center, Los Angeles, CA, USA.
Stephen F MurphyDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Christopher R DethlefsDepartment of Biology, University of Notre Dame, South Bend, IN, USA.
Kara J ShannonDepartment of Biology, University of Notre Dame, South Bend, IN, USA.
Katie R AdlakaDepartment of Biology, University of Notre Dame, South Bend, IN, USA.
Claire E WolfordDepartment of Biology, University of Notre Dame, South Bend, IN, USA.
Vincent J CampitiDepartment of Microbiology and Immunology, Indiana University School of Medicine-South Bend, RCH122, 1234 N. Notre Dame Ave., South Bend, IN, 46617, USA.
Christina V RaghunandanDepartment of Microbiology and Immunology, Indiana University School of Medicine-South Bend, RCH122, 1234 N. Notre Dame Ave., South Bend, IN, 46617, USA.
Randy J SeeleyDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
David L BooneDepartment of Microbiology and Immunology, Indiana University School of Medicine-South Bend, RCH122, 1234 N. Notre Dame Ave., South Bend, IN, 46617, USA. daboone@iu.edu.
University of Notre Dame · USIndiana University School of MedicineIndiana University South Bend · USCedars-Sinai Medical Center · USNorthwestern University · USUniversity of Cincinnati · USUniversity of Michigan–Ann Arbor · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
High Fat Diet-Induced ObesityP01DK056863 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2010
$12.0M
Gastric control of the Intestinal Microbiome and ObesityR21DK110263 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BOONE, DAVID L. · 2016 to 2017
$392k
Metabolic Consequences of bariatric surgery on pregnant and lactating rats and thF32HD068103 · NICHD · UNIVERSITY OF CINCINNATI · PI GRAYSON, BERNADETTE E · 2011 to 2013
$105k
Discovering Gastrokine-1: A Novel Peptide Regulator of Intestinal PermeabilityF32DK089719 · NIDDK · UNIVERSITY OF CHICAGO · PI PASKI, SHIRLEY C · 2011 to 2011
$46k
NCATS NIH HHS UL1 TR001108NICHD NIH HHS F32 HD068103NIDDK NIH HHS 1R21DK110263NIDDK NIH HHS DK056863NIDDK NIH HHS F32 DK089719NIDDK NIH HHS F32DK089719NIDDK NIH HHS P01 DK056863NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R21 DK110263NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Obesity and its sequelae have a major impact on human health. The stomach contributes to obesity in ways that extend beyond its role in digestion, including through effects on the microbiome. Gastrokine-1 (GKN1) is an anti-amyloidogenic protein abundantly and specifically secreted into the stomach lumen. We examined whether GKN1 plays a role in the development of obesity and regulation of the gut microbiome. Gkn1

Indexed as

Angiopoietin-Like Protein 4AnimalsDietFatty LiverFemaleGastric MucosaGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLMice, KnockoutMicrobiotaObesityPeptide HormonesStomachAngiopoietin-Like Protein 4Peptide Hormones

Identifiers

PMID33947892
PMCPMC8096951
OpenAlexW3158938851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.