Evidence map›Paper›PMID 33947763›Full record

ArticlemBio2021

DpaA Detaches Braun's Lipoprotein from Peptidoglycan.

Matthias Winkle, Víctor M Hernández-Rocamora, Karthik Pullela, Emily C A Goodall, Alessandra M Martorana, Joe Gray, Ian R Henderson, Alessandra Polissi, Waldemar Vollmer

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. ΔmSystems · 2026
    Article
  4. Article
  5. Activity Profiling of Mycobacterial L,D-Transpeptidases.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Outer membrane vesicles fromFrontiers in microbiology · 2026
    Article
  8. Article
  9. Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Matthias WinkleCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Víctor M Hernández-RocamoraCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0003-2517-5707
Karthik PullelaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Emily C A GoodallInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-4846-6566
Alessandra M MartoranaDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0003-3996-4141
Joe GrayBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Ian R HendersonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-9954-4977
Alessandra PolissiDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy alessandra.polissi@unimi.it w.vollmer@ncl.ac.uk.ORCID 0000-0003-0903-8024
Waldemar VollmerCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom alessandra.polissi@unimi.it w.vollmer@ncl.ac.uk.ORCID 0000-0003-0408-8567
Newcastle University · GBThe University of Queensland · AUUniversity of Milan · IT

Funding

Biotechnology and Biological Sciences Research Council BB/R017409/1
6 · The paper itself

Abstract

Gram-negative bacteria have a unique cell envelope with a lipopolysaccharide-containing outer membrane that is tightly connected to a thin layer of peptidoglycan. The tight connection between the outer membrane and peptidoglycan is needed to maintain the outer membrane as an impermeable barrier for many toxic molecules and antibiotics.

Indexed as

AmidohydrolasesDiaminopimelic AcidEscherichia coliEscherichia coli ProteinsLipoproteinsPeptidoglycanamidaseAmidohydrolasesDiaminopimelic AcidEscherichia coli ProteinsLipoproteinsPeptidoglycanamidaseBraun’s lipoprotein (Lpp)cell envelopeEscherichia colilipoproteinspeptidoglycanperiplasm

Identifiers

PMID33947763
PMCPMC8263019
OpenAlexW3132139683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.