ArticlemBio2021
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence.
Abstract read
In one paragraph
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity.PLoS pathogens · 2026Article
- 3' UTR-mediated regulation of a protein chaperone by the pspA mRNA in Streptococcus pneumoniae.Nucleic acids research · 2026Article
- The Case for Pneumococcal Surface Protein A (PspA): A Comprehensive Review of a Leading Candidate in Pneumococcal Vaccine Research.Vaccines · 2026Review
- Capsule and PspA Cooperatively Confer Resistance ofInternational journal of molecular sciences · 2026Article
- Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity.bioRxiv : the preprint server for biology · 2025Article
- Virulence factors and therapeutic methods ofVirulence · 2025Review
- Alterations in nutrient availability in the lungs duringInfection and immunity · 2025Article
- Safety and efficacy of an intramuscular bivalent vaccine against influenza and Streptococcus pneumoniae infections in mice.Medical microbiology and immunology · 2025Article
- Genomic analysis and pneumococcal population dynamics across PCV implementation in South Korea, 1997-2023.Microbial genomics · 2025Article
- The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis inMicrobiology spectrum · 2025Article
- Alleviating penicillin-resistant Streptococcus pneumoniae‑induced lung epithelial cell injury: mechanistic insights into effects of the optimized combination of main components from Yinhuapinggan granules.BMC infectious diseases · 2025Article
- Novel processes to obtain pneumococcal surface proteins for vaccines.Applied microbiology and biotechnology · 2025Review
- Streptococcus pneumoniae epidemiology, pathogenesis and control.Nature reviews. Microbiology · 2025Review
- Neuraminidase-mediated enhancement ofmBio · 2025Article
- Biological puzzles solved by usingJournal of bacteriology · 2024Review
- Association between lactate dehydrogenase and ventilator-associated pneumonia risk: an analysis of the MIMIC database 2001-2019.BMC pulmonary medicine · 2024Article
- Elevated lactate dehydrogenase predicts pneumonia in spontaneous intracerebral hemorrhage.Heliyon · 2024Article
- The choline-binding proteins PspA, PspC, and LytA ofInfection and immunity · 2023Article
- An immunoinformatics approach to epitope-based vaccine design against PspA in Streptococcus pneumoniae.Journal, genetic engineering & biotechnology · 2023Article
- Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence.PLoS biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Sang-Sang ParkDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Norberto Gonzalez-JuarbeInfectious Diseases and Genomic Medicine Group, J Craig Venter Institute, Rockville, Maryland, USA.
Eriel MartínezDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Joanetha Yvette HaleDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Yi-Han LinInfectious Diseases and Genomic Medicine Group, J Craig Venter Institute, Rockville, Maryland, USA.
Joshua T HuffinesDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Katherine L KruckowDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
David E Briles *Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA dbriles@uab.edu corihuel@uab.edu.
Carlos J Orihuela *Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA dbriles@uab.edu corihuel@uab.edu.ORCID 0000-0002-8542-4069
Funding
Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4MCardiac microlesion formation during invasive pneumococcal diseaseR01AI114800 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Carlos J Orihuela, Herve S TETTELIN · 2015 to 2026
$5.1MPspA binds necroptotic cells to cause disease and transmitR01AI156898 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ORIHUELA, CARLOS J · 2020 to 2024
$2.0MVaccine potential of the proline-rich domain of pneumococcal surface protein AR01AI118805 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRILES, DAVID E · 2015 to 2019
$1.8MPneumococcal biofilm formation is SpxB dependentR21AI146149 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ORIHUELA, CARLOS J · 2019 to 2020
$427kCapsule protects intracellular pneumococci during vascular endothelial cell translocationR21AI148368 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ORIHUELA, CARLOS J · 2020 to 2021
$408kNIAID NIH HHS R01 AI114800NIAID NIH HHS R01 AI118805NIAID NIH HHS R01 AI156898NIAID NIH HHS R21 AI146149NIAID NIH HHS R21 AI148368NIGMS NIH HHS T32 GM008111
Abstract
Pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC, also called CbpA) are major virulence factors of
Indexed as
Host-Pathogen InteractionsA549 CellsAnimalsBacterial ProteinsFemaleHeat-Shock ProteinsHumansL-Lactate DehydrogenaseMiceMice, Inbred BALB CMice, Inbred C57BLPneumococcal InfectionsProtein BindingStreptococcus pneumoniaeTHP-1 CellsVirulenceBacterial ProteinsHeat-Shock ProteinsL-Lactate Dehydrogenasephage shock protein, BacteriaSpsA protein, Streptococcus pneumoniaeVirulence Factorscholine binding proteinspathogenesispneumococcal surface protein Apneumococcal surface protein CpneumoniaStreptococcus pneumoniaevirulence
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.