Evidence map›Paper›PMID 33947654›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2021

A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States.

Maureen Sanderson, Tuya Pal, Alicia Beeghly-Fadiel, Mary Kay Fadden, Steffie-Ann Dujon, Chrystina Clinton, Cecilia Jimenez, Jennifer Davis, Mieke Fortune, Jasmine Thompson and 8 more

Abstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
  5. The role of breast cancer-related arm lymphedema in physical functioning and physical activity participation among long-term African American breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee. msanderson@mmc.edu.ORCID 0000-0002-3914-6870
Tuya PalVanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Alicia Beeghly-FadielVanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Mary Kay FaddenDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Steffie-Ann DujonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Chrystina ClintonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.ORCID 0000-0002-0384-6277
Cecilia JimenezDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Jennifer DavisDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Mieke FortuneDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Jasmine ThompsonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Kiera BensonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
Nicholas ConleyDepartment of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee.
Sonya ReidVanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Ann TezakVanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Xiao-Ou ShuVanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Wei ZhengVanderbilt-Ingram Cancer Center, Nashville, Tennessee.ORCID 0000-0003-1226-070X
William J BlotVanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Loren LipworthVanderbilt-Ingram Cancer Center, Nashville, Tennessee.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
TrainingU54CA163072 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tuya Pal, Karen Marie Winkfield · 2011 to 2026
$20.1M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Breast Cancer genetic study in African-ancestry populationsR01CA202981 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wei Zheng · 2016 to 2026
$14.1M
The Nashville Breast Health StudyR01CA100374 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 2004 to 2009
$4.2M
Vanderbilt Training Program in Molecular and Genetic Epidemiology of CancerT32CA160056 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Xiao-Ou Shu · 2017 to 2026
$3.8M
Breast Cancer In Blacks: Impact of Genomics, Healthcare Use and Lifestyle on Outcomes (BRIGHT)R01CA204819 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PAL, TUYA · 2017 to 2021
$1.8M
NCATS NIH HHS UL1 TR000445NCI NIH HHS K12 CA090625NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA098131NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA100374NCI NIH HHS R01 CA202981NCI NIH HHS R01 CA204819NCI NIH HHS R03 CA192214NCI NIH HHS R25 CA102209NCI NIH HHS T32 CA160056NCI NIH HHS U01 CA202979NCI NIH HHS U54 CA163069NCI NIH HHS U54 CA163072
6 · The paper itself

Abstract

backgroundWe investigated the association between reproductive risk factors and breast cancer subtype in Black women. On the basis of the previous literature, we hypothesized that the relative prevalence of specific breast cancer subtypes might differ according to reproductive factors.

methodsWe conducted a pooled analysis of 2,188 (591 premenopausal, 1,597 postmenopausal) Black women with a primary diagnosis of breast cancer from four studies in the southeastern United States. Breast cancers were classified by clinical subtype. Case-only polytomous logistic regression models were used to estimate ORs and 95% confidence intervals (CI) for HER2

resultsRelative to women who had ER

conclusionsThis large pooled study of Black women with breast cancer revealed etiologic heterogeneity among breast cancer subtypes. IMPACT: Black parous women who do not breastfeed are more likely to be diagnosed with TNBC, which has a worse prognosis, than with ER

Indexed as

Reproductive HistoryAdultAgedAged, 80 and overBiomarkers, TumorBlack or African AmericanBreastBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedProspective StudiesReceptors, EstrogenReceptors, ProgesteroneRisk FactorsBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, Progesterone

Identifiers

PMID33947654
PMCPMC8254754

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.